All Phenotypes Itgb4<tm1Mfel> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Itgb4^tm1Mfel
targeted mutation 1, Maria Laura Feltri
MGI:3803792

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dag1^tm2Kcam/Dag1^tm2Kcam Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804181
cn2	Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3804179
cn3	Itgb4^tm1Mfel/Itgb4^tm1.1Mfel Tg(Mpz-cre)26Mes/0	involves: 129S2/SvPas * C57BL/6 * FVB/N	MGI:3804180

Allelic Composition	Dag1^tm2Kcam/Dag1^tm2Kcam Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dag1^tm2Kcam mutation (2 available); any Dag1 mutation (109 available)
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:137852 )

• the inner mesaxon appears disorganized

abnormal myelin sheath morphology ( J:137852 )

• abnormally folded myelin with loops, infolding and outfolding is seen in sciatic nerves

• abnormal folding increases with age

demyelination ( J:137852 )

• hypomyelination of the ventral roots that is more severe than in single conditional null Dag1^tm2Kcam mice

• decrease in myelination becomes evident with age and at 12 months of age includes signs of acute demyelination, myelin degeneration, macrophage infiltration, and remyelination

• macrophages are more numerous in double mutants compared to single conditional null Dag1^tm2Kcam mice

abnormal action potential ( J:137852 )

• slight but non significant reduction compared to single conditional null Dag1^tm2Kcam mice

abnormal nerve conduction ( J:137852 )

• slight but non significant increase compared to single conditional null Dag1^tm2Kcam mice

decreased nerve conduction velocity ( J:137852 )

• slight but non significant reduction compared to single conditional null Dag1^tm2Kcam mice

Allelic Composition	Itgb4^tm1Mfel/Itgb4^tm1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological

behavior/neurological phenotype ( J:137852 )

N	• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected

Allelic Composition	Itgb4^tm1Mfel/Itgb4^tm1.1Mfel Tg(Mpz-cre)26Mes/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb4^tm1.1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Itgb4^tm1Mfel mutation (0 available); any Itgb4 mutation (107 available)
Tg(Mpz-cre)26Mes mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelin sheath morphology ( J:137852 )

• progressive increase in the number of myelin infoldings in the sciatic nerve, digital nerve, and anterior roots after 12 months of age

behavior/neurological

behavior/neurological phenotype ( J:137852 )

N	• despite loss of expression in Schwann cells, no tremors, gait abnormalities, or motor skill impairments are detected

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