About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cited2tm2Bha
targeted mutation 2, Shoumo Bhattacharya
MGI:3803778
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0 		involves: 129 * C3H * C57BL/6 * SJL MGI:3804088
cn2
 		Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804085
cn3
 		Cited2tm1Bha/Cited2tm2Bha
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804086
cn4
 		Cited2tm1Bha/Cited2tm2Bha
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: 129 * C57BL/6 * CBA * SJL MGI:3804087


Genotype
MGI:3804088
cn1
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129 * C3H * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (24 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (24 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:137951 )
• 3 of 14 mice exhibit defective cardiac septation and 1 of 14 mice exhibit abnormal left-right patterning
double outlet right ventricle ( J:137951 )
• both the aorta and the pulmonary trunk arise from the right ventricle
right atrial isomerism ( J:137951 )
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
common atrium ( J:137951 )
• common atrium created by complete absence of the primary atrial septum
dextrocardia ( J:137951 )
• in few mice
abnormal heart left ventricle morphology ( J:137951 )
• dextral left ventricle

respiratory system

endocrine/exocrine glands
absent adrenal gland ( J:137951 )
• in 10 of 14 mice

growth/size/body
right atrial isomerism ( J:137951 )
• indicated by bilateral systemic venous sinuses and a common atrium created by complete absence of the primary atrial septum
right pulmonary isomerism ( J:137951 )
• in few mice




Genotype
MGI:3804085
cn2
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (24 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (24 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:137951 )
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning
lethality throughout fetal growth and development, incomplete penetrance ( J:137951 )
• though present in Mendelian ratios at E15.5, mice die during late gestation or postnatal development with no mice present at weaning

cardiovascular system
right aortic arch ( J:137951 )
• in some mice
abnormal inferior vena cava morphology ( J:137951 )
• bilateral in one mouse
common atrioventricular valve ( J:137951 )
• some mice exhibit a common atrioventricular valve
right atrial isomerism ( J:137951 )
• in some mice
dextrocardia ( J:137951 )
• in one mouse
ventricular septal defect ( J:137951 )
• in all embryos at E15.5
abnormal heart left ventricle morphology ( J:137951 )
• abnormal ventricular topology

respiratory system
right pulmonary isomerism ( J:137951 )
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5

nervous system
exencephaly ( J:137951 )
• 2 mice at E15.5

endocrine/exocrine glands

growth/size/body
right atrial isomerism ( J:137951 )
• in some mice
right pulmonary isomerism ( J:137951 )
• in 6 of 10 embryos and associated with right atrial isomerism at E15.5




Genotype
MGI:3804086
cn3
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (24 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (24 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:137951 )
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning
postnatal lethality, incomplete penetrance ( J:137951 )
• despite present in Mendelian ratios at E18.5, fewer than expected survive to weaning

nervous system
exencephaly ( J:137951 )
• in one mouse
abnormal glossopharyngeal ganglion morphology ( J:137951 )
• 11 of 14 mice exhibit fusion of ganglia IX and X
abnormal vagus ganglion morphology ( J:137951 )
• 11 of 14 mice exhibit fusion of ganglia IX and X




Genotype
MGI:3804087
cn4
Allelic
Composition		 Cited2tm1Bha/Cited2tm2Bha
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: 129 * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cited2tm1Bha mutation (3 available); any Cited2 mutation (24 available)
Cited2tm2Bha mutation (2 available); any Cited2 mutation (24 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
ventricular septal defect ( J:137951 )
• while the outflow tract and aortic arch are normal, 3 of 18 mice exhibit septal defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory