Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tcf3tm1.2Mbu targeted mutation 1.2, Meinrad Busslinger MGI:3803639 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• GFP+ pre-B cells are absent in the bone marrow
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• GFP+ pre-B cells are absent in the bone marrow
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization
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• slight
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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• slight
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
|
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• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
|
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
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• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
|
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• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
|
|
• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
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• the spleen contains half the number of B cells as in wild-type mice
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
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• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
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• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
|
|
• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
|
|
• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
|
|
• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
|
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• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
|
|
• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
|
|
• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/07/2025 MGI 6.24 |
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