Analysis Tools
behavior/neurological
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• the anti-manic action of lithium on amphetamine-induced hyperactivity is completely absent in mutants
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• mice spend less time in the open arms of the elevated plus maze, indicating increased anxiety
• in the light/dark transition task, mice show a longer latency to the light chamber, although mice spend similar amounts of time in each changer as wild-type mice
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• in social investigation of an anesthetized mouse target, mutants spend much less time in contact with the target compared to wild-type mice, however there is no difference in the latency to first contact or in the number of contacts with the target
• in a social interaction task in which mice are presented with an unfamiliar juvenile mouse, mutants show a reduction in social interaction time
• on the sociability test, no difference is seen in the amount of time that mutants spend in the two chambers, however mutants spend less time sniffing a stranger 1 mouse cage than the wild-type mice
• in the subsequent social novelty preference test, mutants spend similar amount of time in the two chambers, however mutants spend less time in sniffing the stranger 2 mouse cage than wild-type mice
• in the resident-intruder task, mutants show a similar number of attacks as wild-type mice, indicating normal aggressive behavior
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nervous system
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• EEG signals from the frontal and parietal cortices show a decrease in entropy at different thresholds from those of wild-type mice, indicating increased regularity or decreased complexity in the EEG signals
• EEG signals show lower correlation coefficients between the frontal and parietal cortices in the alpha, beta, and gamma-frequency ranges, indicating decreased EEG synchronization between the two regions
• mice show lower coherence values between the frontal and parietal cortices, indicating a weaker association between the two regions in mutants
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