All Phenotypes Tg(Rr291-lacZ)#Mekk MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Rr291-lacZ)#Mekk
transgene insertion, Marc Ekker
MGI:3802467

Summary

16 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Foxc1^hith/Foxc1^hith Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802474
cx2	m412Asp/m412Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802475
cx3	Dync2h1^m407Asp/Dync2h1^m407Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802478
cx4	Rdh10^m366Asp/Rdh10^m366Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802479
cx5	m357Asp/m357Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802481
cx6	Pcnt^m275Asp/Pcnt^m275Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802482
cx7	Pcnt^m275Asp/Pcnt⁺ Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802483
cx8	m251Asp/m251Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802491
cx9	Pcnt^m239Asp/Pcnt^m239Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802492
cx10	Pcnt^m239Asp/Pcnt⁺ Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802494
cx11	m154Asp/m154Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802495
cx12	m154Asp/m154Asp⁺ Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802496
cx13	Dync2h1^m152Asp/Dync2h1^m152Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802499
cx14	Scrib^m90Asp/Scrib^m90Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802500
cx15	Rfx4^m269Asp/Rfx4^m269Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802502
cx16	Lrp2^m267Asp/Lrp2^m267Asp Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802503

Allelic Composition	Foxc1^hith/Foxc1^hith Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^hith mutation (0 available); any Foxc1 mutation (29 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit midline cortical hypertrophy

Allelic Composition	m412Asp/m412Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit a failure of the thalamocortical axons to invade the cortex

• the intermediate zone of the cortex is thinner than in wild-type mice

Allelic Composition	Dync2h1^m407Asp/Dync2h1^m407Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^m407Asp mutation (0 available); any Dync2h1 mutation (215 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:136795 )

• at E14.5, mice exhibit dorsoventral forebrain patterning defects

Allelic Composition	Rdh10^m366Asp/Rdh10^m366Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rdh10^m366Asp mutation (0 available); any Rdh10 mutation (20 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

thin cerebral cortex ( J:136795 )

• at E14.5, mice exhibit a thinner but expanded cortex compared to wild-type mice

Allelic Composition	m357Asp/m357Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

forebrain hypoplasia ( J:136795 )

• at E14.5

midbrain hyperplasia ( J:136795 )

• at E14.5

craniofacial

abnormal facial morphology ( J:136795 )

• mice exhibit midline facial defects

growth/size/body

abnormal facial morphology ( J:136795 )

• mice exhibit midline facial defects

Allelic Composition	Pcnt^m275Asp/Pcnt^m275Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnt^m275Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:136795 )

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail

polydactyly ( J:136795 )

• anterior

Allelic Composition	Pcnt^m275Asp/Pcnt⁺ Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnt^m275Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:136795 )

• mortality among young adults is increased compared to in wild-type mice

nervous system

sporadic seizures ( J:136795 )

behavior/neurological

sporadic seizures ( J:136795 )

Allelic Composition	m251Asp/m251Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:136795 )

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

limbs/digits/tail

polydactyly ( J:136795 )

• anterior

Allelic Composition	Pcnt^m239Asp/Pcnt^m239Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnt^m239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

• the crispness of the boundary between the subventricular zone and the stream of migrating cells is lost

limbs/digits/tail

polydactyly ( J:136795 )

• anterior

Allelic Composition	Pcnt^m239Asp/Pcnt⁺ Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcnt^m239Asp mutation (0 available); any Pcnt mutation (159 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:136795 )

• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

sporadic seizures ( J:136795 )

nervous system

sporadic seizures ( J:136795 )

Allelic Composition	m154Asp/m154Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:136795 )

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit abnormal interneuron migration in the cerebral cortex

Allelic Composition	m154Asp/m154Asp⁺ Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:136795 )

• mortality among young adults is increased compared to in wild-type mice

behavior/neurological

sporadic seizures ( J:136795 )

nervous system

sporadic seizures ( J:136795 )

Allelic Composition	Dync2h1^m152Asp/Dync2h1^m152Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dync2h1^m152Asp mutation (0 available); any Dync2h1 mutation (215 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit a small posteriorly misshapen cortex

Allelic Composition	Scrib^m90Asp/Scrib^m90Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^m90Asp mutation (0 available); any Scrib mutation (53 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal embryonic neuroepithelium morphology ( J:136795 )

• at E12.5, the neuroepithelium is disorganized and hyperplastic in the cortex and other parts of the nervous system

open neural tube ( J:136795 )

• at the spinal cord and hindbrain at E12.5

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit altered epithelial polarity

embryo

abnormal embryonic neuroepithelium morphology ( J:136795 )

• at E12.5, the neuroepithelium is disorganized and hyperplastic in the cortex and other parts of the nervous system

open neural tube ( J:136795 )

• at the spinal cord and hindbrain at E12.5

Allelic Composition	Rfx4^m269Asp/Rfx4^m269Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfx4^m269Asp mutation (0 available); any Rfx4 mutation (48 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• mice exhibit defect in dorsal midline of the cortex morphology

• dorsal midline structures are lost in the mutant

Allelic Composition	Lrp2^m267Asp/Lrp2^m267Asp Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2^m267Asp mutation (0 available); any Lrp2 mutation (260 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

choroid plexus hyperplasia ( J:136795 )

• in the third ventricle at E14.5

abnormal diencephalon morphology ( J:136795 )

• at E17.5, the dorsal diencephalons is abnormal

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, the cortex is enlarged in the rostrocaudal axis and abnormally shaped

abnormal olfactory bulb morphology ( J:136795 )

• at E17.5

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