Phenotypes associated with this allele

• Allele Symbol: Fzr1^tm1.1Mama
• Allele Name: targeted mutation 1.1, Marcos Malumbres
• Allele ID: MGI:3800719
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzr1^tm1.1Mama/Fzr1^tm1.1Mama	involves: BALB/cJ * C57BL/6 * SJL	MGI:3801165
ht2	Fzr1^tm1.1Mama/Fzr1^+	involves: BALB/cJ * C57BL/6 * SJL	MGI:3801168
cn3	Fzr1^tm1Mama/Fzr1^tm1.1Mama Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: BALB/cJ * C57BL/6 * SJL	MGI:3801167

Genotype
MGI:3801165

hm1

• Allelic Composition: Fzr1^tm1.1Mama/Fzr1^tm1.1Mama
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:137456 )

• mice die between E11.5 and E12.5

embryo

embryonic growth retardation ( J:137456 )

abnormal trophoblast giant cell morphology ( J:137456 )

• underdeveloped with small nuclei

placental labyrinth hypoplasia ( J:137456 )

• between E10.5 and E11.5

pale placenta ( J:137456 )

• between E10.5 and E11.5

hematopoietic system

decreased erythroid progenitor cell number ( J:137456 )

• between E10.5 and E11.5, the number of erythroblasts is decreased compared to in wild-type mice

cellular

decreased cell proliferation ( J:137456 )

• in mouse embryonic fibroblasts

growth/size/body

embryonic growth retardation ( J:137456 )

Genotype
MGI:3801168

ht2

• Allelic Composition: Fzr1^tm1.1Mama/Fzr1⁺
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

mortality/aging

premature death ( J:137456 )

• survival compared to wild-type mice decreases after 25 months of age with all mice dead by 30 months

neoplasm

decreased incidence of tumors by chemical induction ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

decreased tumor growth/size ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

increased tumor incidence ( J:137456 )

• aged mice develop more frequent epithelial neoplasias such as mammary adenocarcinomas and fibroadenomas (in females) as well as tumors in the lung, liver, kidney, testis and sebaceous glands compared to wild-type mice

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

increased liver tumor incidence ( J:137456 )

• in aged mice

increased lung tumor incidence ( J:137456 )

• in aged mice

nervous system

abnormal postnatal subventricular zone morphology ( J:137456 )

• mice exhibit increased proliferation in cells of the subventricular zone

• however, no alterations in brain structures are detected

behavior/neurological

abnormal object recognition memory ( J:137456 )

• object recognition is reduced compared to in wild-type mice

abnormal motor coordination/balance ( J:137456 )

• mice exhibit increased falling off of a circular rod compared to wild-type mice

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:137456 )

• young mice develop fewer and smaller tumors in a classical skin carcinogenesis protocol (DMBA and TPA induction) compared to similarly treated wild-type mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

reproductive system

increased testis tumor incidence ( J:137456 )

♂ • in aged mice

integument

increased mammary gland tumor incidence ( J:137456 )

• aged female mice develop mammary adenocarcinomas and fibroadenomas more frequently than wild-type mice

increased mammary adenocarcinoma incidence ( J:137456 )

• in aged female mice

respiratory system

increased lung tumor incidence ( J:137456 )

• in aged mice

liver/biliary system

increased liver tumor incidence ( J:137456 )

• in aged mice

Genotype
MGI:3801167

cn3

• Allelic Composition: Fzr1^tm1Mama/Fzr1^tm1.1Mama; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

mortality/aging

mortality/aging ( J:137456 )

N • mice survive up to P3

embryo

embryo phenotype ( J:137456 )

N • mice survive embryogenesis with normal placentas and trophoblast cells