Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd2Gt(RRBO46)Byg mutation
(0 available);
any
Chd2 mutation
(189 available)
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mortality/aging
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• while mice are present in Mendelian ratios at E18.5, no mice are observed at weaning
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cellular
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• X-ray exposed mouse embryonic fibroblasts exhibit a moderately higher increase in G1-S phase compared to similarly treated wild-type cells
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• 25% of mouse embryonic fibroblasts (MEFs) exhibit numerous DNA breaks unlike wild-type MEFs
• treatment of MEFs with X-ray causes more DNA damage than in similarly treated wild-type MEFs that persists for longer than in wild-type MEFs
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hematopoietic system
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• clusters of hematopoietic cells are less organized compared to in wild-type mice
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• mice exhibit impaired erythropoiesis with decreased expression of CD71 and CD117 but not Ter119 in fetal liver cells compared to in wild-type mice
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cardiovascular system
behavior/neurological
growth/size/body
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• at E18.5, mice exhibit profound growth retardation compared to wild-type mice
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd2Gt(RRBO46)Byg mutation
(0 available);
any
Chd2 mutation
(189 available)
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mortality/aging
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• fewer than expected mice are present at E14.5
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• despite some mice present at P1, no mice are present at weaning
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cardiovascular system
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• mild to moderate in some neonates
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growth/size/body
integument
vision/eye
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• 2 of 15 mice exhibit defective eye formation and eye migration defects
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Allelic
Composition |
Chd2Gt(RRBO46)Byg/Chd2+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd2Gt(RRBO46)Byg mutation
(0 available);
any
Chd2 mutation
(189 available)
|
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mortality/aging
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• not all mice survive beyond weaning
(J:146176)
• fewer than expected mice survive beyond weaning
(J:146743)
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• median lifespan of 52.3 weeks, most mice succumb to lymphomas by week 58, and all mice are dead by 100 weeks
(J:146176)
• by 32 weeks of age 50% of mice die whereas all wild-type mice are alive
(J:146743)
• by 64 weeks 94% of mice die whereas all wild-type mice are alive
(J:146743)
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• some mice do not survive beyond weaning
(J:146176)
• fewer than expected mice survive the first 4 days after birth
(J:146743)
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cardiovascular system
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• primarily involving the left ventricular free wall and septum
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• primarily involving the left ventricular free wall and septum
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• in 57% of mice primarily involving the left ventricular free wall and septum
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respiratory system
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• 20% of mice exhibit lung alterations including interstitial pneumonia, alveolar hemorrhage, and alveolar edema
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• as early as 16 weeks of age
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liver/biliary system
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• centrilobular and coagulative in 28% of mice
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renal/urinary system
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• mice exhibit nephropathy unlike wild-type mice
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• 85% of mice exhibit bilateral glomerulopathy with global glomerular enlargement due to hypercellularity and increased matrix amount unlike in wild-type mice
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homeostasis/metabolism
hematopoietic system
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• in 67% of spleens due to an expansion of red pulp
(J:146743)
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• CD44 high CD4+ T cells are increased in mice with hyperplasia or lymphomas
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• in spleens and lymph nodes
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• due to increased erythroid and myeloid cells
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behavior/neurological
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• as early as 16 weeks of age
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growth/size/body
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• reduction in body size compared to wild-type mice at birth
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• the reduction in body size compared to wild-type mice observed at birth is less pronounced at 3 to 4 months of age
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• at 8 to 10 months of age
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adipose tissue
immune system
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• in 57% of mice primarily involving the left ventricular free wall and septum
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• CD44 high CD4+ T cells are increased in mice with hyperplasia or lymphomas
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• in spleens and lymph nodes
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• due to increased erythroid and myeloid cells
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• 3 mice exhibit generalized lymphadenopathy characterized by non-specific, reactive lymphoid hyperplasia unlike in wild-type mice
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• most mice succumb to splenic, lymph node, and thymic lymphomas and lymphoid hyperplasias by week 58
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muscle
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• primarily involving the left ventricular free wall and septum
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skeleton
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• at 8 to 10 months of age
(J:146176)
• as early as 16 weeks of age
(J:146743)
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• at 8 to 10 months of age
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neoplasm
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• lymphomas are first observed at 26 weeks of age
• most mice succumb to splenic, lymph node, and thymic lymphomas and lymphoid hyperplasias by week 58
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endocrine/exocrine glands
integument
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• as early as 16 weeks of age, mice have scruffy coats unlike wild-type mice
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cellular
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• centrilobular and coagulative in 28% of mice
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Allelic
Composition |
Chd2Gt(RRBO46)Byg/Chd2+
|
|
Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chd2Gt(RRBO46)Byg mutation
(0 available);
any
Chd2 mutation
(189 available)
|
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mortality/aging
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• fewer than expected mice are present at weaning
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reproductive system
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• cystic endometrial hyperplasia in 3 of 8 female mice
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• cystic endometrial hyperplasia in 3 of 8 female mice
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adipose tissue
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• absent or extremely hypoplastic
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• absent or extremely hypoplastic
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cardiovascular system
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• filling defects in the distal vasculature of the distal extremities
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• mild to moderate in some neonates
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growth/size/body
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• cystic endometrial hyperplasia in 3 of 8 female mice
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integument
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• absent or extremely hypoplastic
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• absent or extremely hypoplastic
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renal/urinary system
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• glomerulonephropathy in 15 of 32 adult mice
• however, neonatal mice exhibit normal renal histopathology
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skeleton
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• lordokyphosis at 4 months
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Analysis Tools