Phenotypes associated with this allele

• Allele Symbol: Tg(CD2-Foxj1)#Stlp
• Allele Name: transgene insertion, Stanford L Peng
• Allele ID: MGI:3800438
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Fas^lpr/Fas^lpr Tg(CD2-Foxj1)#Stlp/0	MRL.Cg-Fas^lpr Tg(CD2-Foxj1)#Stlp	MGI:3800459
tg2	Tg(CD2-Foxj1)#Stlp/0	C57BL/6-Tg(CD2-Foxj1)#Stlp	MGI:3800460

Genotype
MGI:3800459

cx1

• Allelic Composition: Fas^lpr/Fas^lpr; Tg(CD2-Foxj1)#Stlp/0
• Genetic Background: MRL.Cg-Fas^lpr Tg(CD2-Foxj1)#Stlp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

increased double-negative T cell number ( J:122222 )

• diminished accumulation of CD3+ CD4- CD8- B220+ double negative T cells is observed in peripheral lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• peripheral CD4 counts are 8- to 10-fold reduced

abnormal T cell physiology ( J:122222 )

• increased numbers of mature CD4+ thymocytes show defective migration in response to CCL19 in vitro, suggesting impaired ability to emigrate from the thymus

enlarged lymph nodes ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

decreased susceptibility to systemic lupus erythematosus ( J:122222 )

• double mutant mice display protection against murine lupus (reduced lymphadenopathy, autoantibody production and end-organ disease)

increased anti-nuclear antigen antibody level ( J:122222 )

• anti-DNA autoantibodies are produced; however, these autoantibodies are not high affinity anti-dsDNA antibodies and likely only low affinity anti-ssDNA antibodies are present

liver inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

kidney inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

lung inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

hematopoietic system

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

increased double-negative T cell number ( J:122222 )

• diminished accumulation of CD3+ CD4- CD8- B220+ double negative T cells is observed in peripheral lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• peripheral CD4 counts are 8- to 10-fold reduced

abnormal T cell physiology ( J:122222 )

• increased numbers of mature CD4+ thymocytes show defective migration in response to CCL19 in vitro, suggesting impaired ability to emigrate from the thymus

renal/urinary system

kidney inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

endocrine/exocrine glands

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

digestive/alimentary system

salivary gland inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

liver/biliary system

liver inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

respiratory system

lung inflammation ( J:122222 )

• inflammation observed is reduced compared to non-transgenic Fas^lpr mice

growth/size/body

enlarged spleen ( J:122222 )

• reduced lymphadenopathy is observed compared to non-transgenic Fas^lpr mice

Genotype
MGI:3800460

tg2

• Allelic Composition: Tg(CD2-Foxj1)#Stlp/0
• Genetic Background: C57BL/6-Tg(CD2-Foxj1)#Stlp

immune system

immune system phenotype ( J:122222 )

N • no increased apoptosis of CD4 cells centrally or in the periphery is detected

N • comparable numbers of CD4+CD8+ double positive thymocytes are observed relative to wild-type controls

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• reduced centrally compared to wild-type; this is also seen in peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:122222 )

• reduced centrally compared to wild-type; this is also seen in peripheral blood

increased single-positive T cell number ( J:122222 )

• there is an increased proportion of CD4+CD8- cells in the thymus

abnormal T cell physiology ( J:122222 )

• CD4+ and CD8+ thymocytes show significantly defective migration in response to CCL19 in transwell assays in vitro, suggesting impaired ability to emigrate from the thymus

lymphoid hypoplasia ( J:122222 )

• reduced cellularity compared to non-transgenic

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:122222 )

• reduced centrally compared to wild-type; this is also seen in peripheral blood

decreased CD8-positive, alpha-beta T cell number ( J:122222 )

• reduced centrally compared to wild-type; this is also seen in peripheral blood

increased single-positive T cell number ( J:122222 )

• there is an increased proportion of CD4+CD8- cells in the thymus

abnormal T cell physiology ( J:122222 )

• CD4+ and CD8+ thymocytes show significantly defective migration in response to CCL19 in transwell assays in vitro, suggesting impaired ability to emigrate from the thymus