Analysis Tools
nervous system
| N |
• despite neuron loss, no neurofibrillary tangles or plaques are observed
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• mice exhibit a loss of white matter axons in the cerebellum
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• mice exhibit a loss of granular neurons in the cerebellum
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• the molecular layer in the cerebellum is atrophic
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• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell
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astrocytosis
(
J:125549
)
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• moderate
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• mice exhibit neuron loss accompanied by disorganization of remaining neurons with degenerative changes in their axon lengths
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• normal axoplasm is replaced with axonal swelling with focal accumulation of organelles and often progresses to collapse of the axon
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• dendritic processes in the CA1 region of the hippocampus exhibit collapse, vacuolization and reduction in complexity
• Purkinje dendritic processes are tortuous, dilated and exhibit reduced branching
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• dendritic processes are tortuous, dilated and exhibit reduced branching
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• neuronal damage
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• mice exhibit spongiform lesions particularly in the cerebellum where loss of white matter axons, Purkinje cells and granular neurons is observed
• mice exhibit spongiform degradation in astrocytes ranging from swelling of astrocytic foot processes to vacuolar changes in the entire cell
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behavior/neurological
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• mice exhibit less severe neurological defects than observed in Tg(Gfap-Il6)G16Lms founder mouse by 1 month of age
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paraparesis
(
J:125549
)
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• hindlimb weakness
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cardiovascular system
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• marked in the cerebellum
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growth/size/body
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• at 1 to 2 weeks of age
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