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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MtTGFA)Lmb
transgene insertion, Glenn Merlino
MGI:3800163
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0 		involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:5792847
cx2
 		Tg(Alb1-Myc)#Sst/0
Tg(MtTGFA)Lmb/0 		involves: C57BL/6 * CBA * CD-1 MGI:5792957
tg3
 		Tg(MtTGFA)Lmb/0 involves: CD-1 MGI:5792850


Genotype
MGI:5792847
cn1
Allelic
Composition		 Smad4tm1.1Gsu/Smad4tm1.1Gsu
Ptf1atm1.1(cre)Cvw/Ptf1a+
Tg(MtTGFA)Lmb/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (30 available)
Smad4tm1.1Gsu mutation (0 available); any Smad4 mutation (43 available)
Tg(MtTGFA)Lmb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) mice

endocrine/exocrine glands
abnormal pancreas morphology ( J:229184 )
• activated pancreatic fibroblasts or stellate cells (PSCs) are seen in areas surrounding the ductal lesions in mice treated with zinc sulfate
abnormal pancreatic acinar cell morphology ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit progressive dilatation of the acinar lumen due to acinar-to-ductal metaplasia
• mice treated with zinc sulfate water for 8 months show a decrease in height of acinar cells
abnormal pancreatic duct morphology ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit increased ductal proliferation
dilated pancreatic duct ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit pancreatic duct dilation
abnormal pancreatic islet morphology ( J:229184 )
• disruption of islet cells due to ductal proliferation and increased fibrosis is seen in mice provided with zinc sulfate
enlarged pancreas ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit enlarged fibrotic pancreata
pancreas cyst ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit frequent cystic formation in the pancreas due to duct dilation
pancreas fibrosis ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit pronounced interlobular fibrosis and progressive accumulation of fibrotic stroma and fibroblasts
pancreatic acinar-to-ductal metaplasia ( J:229184 )
• mice provided with zinc sulfate in water for 8 months to induce TGFA expression exhibit acinar-to-ductal metaplasia
• proliferation within the metaplastic ductal epithelia is increased compared to single Tg(MtTGFA)Lmb hemizygotes
increased pancreatic intraepithelial neoplasia incidence ( J:229184 )
• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)
• the number of PanIN-1 and -2 lesions is higher than in single Tg(MtTGFA)Lmb hemizygotes
• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors
chronic pancreas inflammation ( J:229184 )
• marker analysis shows increased upregulation of markers associated with chronic pancreatitis and desmoplasia in mice treated with zinc sulfate

immune system
chronic pancreas inflammation ( J:229184 )
• marker analysis shows increased upregulation of markers associated with chronic pancreatitis and desmoplasia in mice treated with zinc sulfate

neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:229184 )
• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)
• the number of PanIN-1 and -2 lesions is higher than in single Tg(MtTGFA)Lmb hemizygotes
• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

digestive/alimentary system
abnormal pancreatic acinar cell morphology ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit progressive dilatation of the acinar lumen due to acinar-to-ductal metaplasia
• mice treated with zinc sulfate water for 8 months show a decrease in height of acinar cells
abnormal pancreatic duct morphology ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit increased ductal proliferation
dilated pancreatic duct ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit pancreatic duct dilation

growth/size/body
enlarged pancreas ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit enlarged fibrotic pancreata
pancreas cyst ( J:229184 )
• mice treated with zinc sulfate water for 8 months exhibit frequent cystic formation in the pancreas due to duct dilation




Genotype
MGI:5792957
cx2
Allelic
Composition		 Tg(Alb1-Myc)#Sst/0
Tg(MtTGFA)Lmb/0
Genetic
Background		 involves: C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased hepatocellular carcinoma incidence ( J:176432 )
• hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months
• by 9 months, more than 90% of mice develop hepatocellular carcinoma

hematopoietic system
decreased NK cell number ( J:176432 )
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers
increased NK T cell number ( J:176432 )
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

immune system
decreased NK cell number ( J:176432 )
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers
increased NK T cell number ( J:176432 )
• the relative contribution of hepatic natural killer (Cd49b+CD3-) and natural killer T (Cd49b+CD3+) cells is altered with the proportion of NK cells reduced and proportion of NKT cells increased in dysplastic livers

liver/biliary system
increased hepatocellular carcinoma incidence ( J:176432 )
• hepatocarcinogenesis progresses from early (3 weeks) and severe hepatocyte dysplasia (3 months) to preneoplastic focal lesions and hepatocellular carcinoma within 4 months
• by 9 months, more than 90% of mice develop hepatocellular carcinoma

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
 J:176432




Genotype
MGI:5792850
tg3
Allelic
Composition		 Tg(MtTGFA)Lmb/0
Genetic
Background		 involves: CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Pancreatic fibrosis and acinar-to-ductal metaplasia in Tg(MtTGFA)Lmb/0 (MT-TGFalpha) and Smad4tm1.1Gsu/Smad4tm1.1Gsu Ptf1atm1.1(cre)Cvw/Ptf1a+ Tg(MtTGFA)Lmb/0 (STP) mice

endocrine/exocrine glands
abnormal pancreas morphology ( J:229184 )
• pancreas of mice provided with zinc sulfate in water undergoes progressive transformation characterized by diffuse fibrosis and altered acinar cell structure, acinar-to-ductal metaplasia, ductal proliferation, and dilatation
abnormal pancreatic acinar cell morphology ( J:229184 )
• pancreas of mice provided with zinc sulfate in water for 8 months show altered acinar structure
abnormal pancreatic islet morphology ( J:229184 )
• disruption of islet cells due to ductal proliferation and increased fibrosis is seen in mice provided with zinc sulfate
pancreas fibrosis ( J:229184 )
• mice provided with zinc sulfate in water for 8 months exhibit diffuse fibrosis and progressive accumulation of fibrotic stroma and fibroblasts
pancreatic acinar-to-ductal metaplasia ( J:229184 )
• mice provided with zinc sulfate in water for 8 months exhibit acinar-to-ductal metaplasia
increased pancreatic intraepithelial neoplasia incidence ( J:229184 )
• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)
• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

neoplasm
increased pancreatic intraepithelial neoplasia incidence ( J:229184 )
• mice treated with zinc sulfate water show increased numbers of ductal structures (both metaplastic ducts and/or PanIN-1 and -2)
• however, mice treated with zinc sulfate water do no develop malignant pancreatic tumors

digestive/alimentary system
abnormal pancreatic acinar cell morphology ( J:229184 )
• pancreas of mice provided with zinc sulfate in water for 8 months show altered acinar structure




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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory