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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox5tm2Vlf
targeted mutation 2, Veronique Lefebvre
MGI:3799354
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox5tm2Vlf/Sox5tm2Vlf involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3800352
cn2
 		Sox5tm2Vlf/Sox5tm2Vlf
Tg(Prrx1-cre)1Cjt/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3800355
cn3
 		Sox5tm2Vlf/Sox5tm2Vlf
Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL MGI:3800358


Genotype
MGI:3800352
hm1
Allelic
Composition		 Sox5tm2Vlf/Sox5tm2Vlf
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm2Vlf mutation (1 available); any Sox5 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137217 )
• normal behavior
• externally indistinguishable from controls




Genotype
MGI:3800355
cn2
Allelic
Composition		 Sox5tm2Vlf/Sox5tm2Vlf
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm2Vlf mutation (1 available); any Sox5 mutation (45 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137217 )
• normal appearance at birth
• viable and fertile




Genotype
MGI:3800358
cn3
Allelic
Composition		 Sox5tm2Vlf/Sox5tm2Vlf
Sox6tm2.1Vlf/Sox6tm2.1Vlf
Tg(Prrx1-cre)1Cjt/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox5tm2Vlf mutation (1 available); any Sox5 mutation (45 available)
Sox6tm2.1Vlf mutation (1 available); any Sox6 mutation (58 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:137217 )
• small size

limbs/digits/tail
abnormal autopod morphology ( J:137217 )
• paws lack mineralized bone
abnormal radius morphology ( J:137217 )
• lacks cartillage
abnormal ulna morphology ( J:137217 )
• lacks cartillage
abnormal fibula morphology ( J:137217 )
• lacks cartillage
abnormal tibia morphology ( J:137217 )
• lacks cartillage

skeleton
abnormal radius morphology ( J:137217 )
• lacks cartillage
abnormal ulna morphology ( J:137217 )
• lacks cartillage
abnormal fibula morphology ( J:137217 )
• lacks cartillage
abnormal tibia morphology ( J:137217 )
• lacks cartillage
short sternum ( J:137217 )
• at birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory