Phenotypes associated with this allele
Allelic
Composition |
Tbx6rv/Tbx6tm2Pa
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Genetic
Background |
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57L/J * ICR |
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embryo
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N |
• unlike in null mice, direction of embryo turning is similar to controls
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cardiovascular system
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N |
• unlike in null mice, the direction of heart looping is similar to controls
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Allelic
Composition |
Tbx6tm1Pa/Tbx6tm2Pa
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR |
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embryo
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• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
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• direction of turning is completely reversed in 18% (7 of 38) of embryos and partially reversed in an additional 4 embryos
• embryos with reversal of turning direction do not always also have reversal of the direction of heart looping
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cardiovascular system
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• at E9.5 - E10.5, about 40% of embryos show either completely reversed or ventral rather than horizontal looping
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cellular
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• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
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Allelic
Composition |
Tbx6tm2Pa/Tbx6+
Wnt3atm1Amc/Wnt3a+
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Genetic
Background |
involves: 129 * 129S1/Sv * 129X1/SvJ * ICR |
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embryo
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N |
• despite decrease in Wnt3a expression in Tbx6 null mice, no defects in somite formation are detected
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cardiovascular system
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N |
• unlike in Tbx6 null mice, the direction of heart looping is similar to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6tm2Pa mutation
(1 available);
any
Tbx6 mutation
(17 available)
Tg(CAG-GFP/MAPT)1Pa mutation
(0 available)
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embryo
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• image trace analysis suggests an increase in the number of short cilia
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• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia
• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased
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• intracellular calcium asymmetries normally present around the node are absent
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cellular
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• image trace analysis suggests an increase in the number of short cilia
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• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia
• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased
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Analysis Tools