All Phenotypes Tbx6<tm2Pa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx6^tm2Pa
targeted mutation 2, Virginia Papaioannou
MGI:3798467

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tbx6^rv/Tbx6^tm2Pa	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57L/J * ICR	MGI:3804666
ht2	Tbx6^tm1Pa/Tbx6^tm2Pa	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR	MGI:3804665
cx3	Tbx6^tm2Pa/Tbx6⁺ Wnt3a^tm1Amc/Wnt3a⁺	involves: 129 * 129S1/Sv * 129X1/SvJ * ICR	MGI:3804667
cx4	Tbx6^tm2Pa/Tbx6^tm2Pa Tg(CAG-GFP/MAPT)1Pa/?	involves: 129 * 129S1/Sv * 129X1/SvJ * ICR	MGI:3804668

Allelic Composition	Tbx6^rv/Tbx6^tm2Pa
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57L/J * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6^rv mutation (1 available); any Tbx6 mutation (19 available)
Tbx6^tm2Pa mutation (1 available); any Tbx6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:137163 )

N	• unlike in null mice, direction of embryo turning is similar to controls

cardiovascular system

cardiovascular system phenotype ( J:137163 )

N	• unlike in null mice, the direction of heart looping is similar to controls

Allelic Composition	Tbx6^tm1Pa/Tbx6^tm2Pa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6^tm1Pa mutation (1 available); any Tbx6 mutation (19 available)
Tbx6^tm2Pa mutation (1 available); any Tbx6 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal motile primary cilium morphology ( J:137163 )

• some cilia are shorter and thicker

• most cilia have terminal bulges or balloon like structures

abnormal direction of embryo turning ( J:137163 )

• direction of turning is completely reversed in 18% (7 of 38) of embryos and partially reversed in an additional 4 embryos

• embryos with reversal of turning direction do not always also have reversal of the direction of heart looping

cardiovascular system

abnormal direction of heart looping ( J:137163 )

• at E9.5 - E10.5, about 40% of embryos show either completely reversed or ventral rather than horizontal looping

cellular

abnormal motile primary cilium morphology ( J:137163 )

• some cilia are shorter and thicker

• most cilia have terminal bulges or balloon like structures

Allelic Composition	Tbx6^tm2Pa/Tbx6⁺ Wnt3a^tm1Amc/Wnt3a⁺
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6^tm2Pa mutation (1 available); any Tbx6 mutation (19 available)
Wnt3a^tm1Amc mutation (1 available); any Wnt3a mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:137163 )

N	• despite decrease in Wnt3a expression in Tbx6 null mice, no defects in somite formation are detected

cardiovascular system

cardiovascular system phenotype ( J:137163 )

N	• unlike in Tbx6 null mice, the direction of heart looping is similar to controls

Allelic Composition	Tbx6^tm2Pa/Tbx6^tm2Pa Tg(CAG-GFP/MAPT)1Pa/?
Genetic Background	involves: 129 * 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6^tm2Pa mutation (1 available); any Tbx6 mutation (19 available)
Tg(CAG-GFP/MAPT)1Pa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryonic cilium length ( J:137163 )

• image trace analysis suggests an increase in the number of short cilia

abnormal motile primary cilium physiology ( J:137163 )

• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia

• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased

abnormal embryo development ( J:137163 )

• intracellular calcium asymmetries normally present around the node are absent

cellular

decreased embryonic cilium length ( J:137163 )

• image trace analysis suggests an increase in the number of short cilia

abnormal motile primary cilium physiology ( J:137163 )

• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia

• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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