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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wdr77tm1Zwan
targeted mutation 1, Zhengxin Wang
MGI:3798419
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wdr77tm1Zwan/Wdr77tm1Zwan involves: 129P2/OlaHsd * C57BL/6J MGI:3804868
ht2
 		Wdr77tm1Zwan/Wdr77+ involves: 129P2/OlaHsd * C57BL/6J MGI:3804867


Genotype
MGI:3804868
hm1
Allelic
Composition		 Wdr77tm1Zwan/Wdr77tm1Zwan
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr77tm1Zwan mutation (0 available); any Wdr77 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:137003 )
• embryos die before E8.5, for unknown reasons




Genotype
MGI:3804867
ht2
Allelic
Composition		 Wdr77tm1Zwan/Wdr77+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wdr77tm1Zwan mutation (0 available); any Wdr77 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal prostate gland epithelium morphology ( J:137003 )
• parallel alignment of epithelial cells is lost in 6- and 12-month old mice
prostate gland epithelial hyperplasia ( J:137003 )
• epithelial cells are hyperplastic; prominent nucleoli are observed in nuclei of hyperplastic epithelial cells at 2, 6, and 12 months
prostate gland hyperplasia ( J:137003 )
• at 2 months of age, >70% of males display multifocal hyperplasia of dorsal prostate, with hyperplastic epithelial cells filling the prostate glands; hyperplasia is observed at 6 and 12 months in >30% of males
• no hyperplasia is seen in ventral part of prostate
• castrated males do not develop prostatic hyperplasia

reproductive system
abnormal prostate gland epithelium morphology ( J:137003 )
• parallel alignment of epithelial cells is lost in 6- and 12-month old mice
prostate gland epithelial hyperplasia ( J:137003 )
• epithelial cells are hyperplastic; prominent nucleoli are observed in nuclei of hyperplastic epithelial cells at 2, 6, and 12 months
prostate gland hyperplasia ( J:137003 )
• at 2 months of age, >70% of males display multifocal hyperplasia of dorsal prostate, with hyperplastic epithelial cells filling the prostate glands; hyperplasia is observed at 6 and 12 months in >30% of males
• no hyperplasia is seen in ventral part of prostate
• castrated males do not develop prostatic hyperplasia

neoplasm
neoplasm ( J:137003 )
N
• no tumors develop in mice up to 12 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory