Wdr77^tm1Zwan
Targeted Allele Detail

Summary

• Symbol: Wdr77^tm1Zwan
• Name: WD repeat domain 77; targeted mutation 1, Zhengxin Wang
• MGI ID: MGI:3798419
• Synonyms: p44^-
• Gene: Wdr77 Location: Chr3:105866814-105877076 bp, + strand Genetic Position: Chr3, 46.46 cM
• Alliance: Wdr77^tm1Zwan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137003
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing part of exon 1 and exons 2 through 4 was replaced with a neo cassette. This results in ablation of amino acids 1 to 154. Reduction in protein expression was confirmed by western blot analysis on prostate extracts of heterozygous mice. (J:137003)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wdr77 Mutation: 17 strains or lines available

References

• Original: J:137003 Zhou L, et al., Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. J Mol Endocrinol. 2006 Oct;37(2):283-300
• All: 1 reference(s)