All Phenotypes Fzd5<tm1Nat> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fzd5^tm1Nat
targeted mutation 1, Jeremy Nathans
MGI:3796576

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzd5^tm1Nat/Fzd5^tm1Nat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3807220
cn2	Fzd5^tm1Nat/Fzd5^tm2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	MGI:3807221
cn3	Fzd5^tm1Nat/Fzd5^tm2Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	MGI:3807225

Allelic Composition	Fzd5^tm1Nat/Fzd5^tm1Nat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd5^tm1Nat mutation (1 available); any Fzd5 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:136390 )

• embryos die at midgestation

Allelic Composition	Fzd5^tm1Nat/Fzd5^tm2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Fzd5^tm1Nat mutation (1 available); any Fzd5 mutation (33 available)
Fzd5^tm2Nat mutation (1 available); any Fzd5 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:136390 )

• animals exhibit 15-20% reduction in body size and weight

decreased body weight ( J:136390 )

nervous system

abnormal thalamus morphology ( J:136390 )

• parafascicular nucleus (PFN) exhibits loss of 50% of all neurons, and nearly 100% of Fzd5-expressing neurons at 8 weeks

• neurons are present in normal numbers and show normal projections to the striatum at P1, then are gradually lost during the first postnatal month

behavior/neurological

impaired coordination ( J:136390 )

• mice consistently show compromised performance in rotarod tests compared to heterozygous controls

vision/eye

retina degeneration ( J:136390 )

• mice display slow retinal degeneration

Allelic Composition	Fzd5^tm1Nat/Fzd5^tm2Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd5^tm1Nat mutation (1 available); any Fzd5 mutation (33 available)
Fzd5^tm2Nat mutation (1 available); any Fzd5 mutation (33 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (3 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal thalamus morphology ( J:136390 )

• PFN in adults displays nearly complete loss of alkaline phosphatase expressing Fzd5-null neurons by 10 days after 4HT injection and cre activation, but no loss is observed in Fzd5^tm2Nat/+, cre-positive control PFNs 8 days after 4HT treatment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23