All Phenotypes Klf5<Gt(XB751)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf5^Gt(XB751)Byg/Klf5^Gt(XB751)Byg	B6.129P2-Klf5^Gt(XB751)Byg	MGI:3809589
ht2	Klf5^Gt(XB751)Byg/Klf5⁺	B6.129P2-Klf5^Gt(XB751)Byg	MGI:3809590

Allelic Composition	Klf5^Gt(XB751)Byg/Klf5^Gt(XB751)Byg
Genetic Background	B6.129P2-Klf5^Gt(XB751)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf5^Gt(XB751)Byg mutation (0 available); any Klf5 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:168150 )

• embryos arrested at the blastocyst stage

• heterozygous intercrosses revealed no null embryos between E6.5 and E8.5

embryo

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

failure of blastocyst to hatch from the zona pellucida ( J:168150 )

• morulae cultured failed to hatch embryos and eventually collapsed

absent blastocoele ( J:168150 )

• the majority of E3.5 mutant embryos had either no cavity or a small cavity

cellular

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:136125 )

• crypt heights in the distal colon are reduced by 11% compared to wild-type controls

• the increase in crypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells is seen in infected or uninfected mice compared to controls

immune system

abnormal response to infection ( J:136125 )

• the increase in dital coloncrypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of distal colon crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells in distal colon crypts is seen in infected or uninfected mice compared to controls

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:136125 )

• crypt heights in the distal colon are reduced by 11% compared to wild-type controls

• the increase in crypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells is seen in infected or uninfected mice compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23