All Phenotypes Trp63<tm1Aam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trp63^tm1Aam
targeted mutation 1, Alea A Mills
MGI:3795257

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp63^tm1Aam/Trp63^tm1Aam	Not Specified	MGI:3797855
ht2	Trp63^tm1Aam/Trp63⁺	Not Specified	MGI:3797857
cx3	Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi Trp63^tm1Aam/Trp63^tm1Aam	involves: 129P2/OlaHsd	MGI:3797869
cx4	Trp63^tm1Aam/Trp63^tm1Aam Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi	involves: 129P2/OlaHsd	MGI:3797872

Allelic Composition	Trp63^tm1Aam/Trp63^tm1Aam
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63^tm1Aam mutation (0 available); any Trp63 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:135784 )

embryo

abnormal ectoderm development ( J:135784 )

• mice exhibit ectodermal dysplasia

abnormal apical ectodermal ridge morphology ( J:135784 )

• unstratified

small limb buds ( J:135784 )

• limb buds are small and have a pointed shape unlike in wild-type mice

limbs/digits/tail

abnormal apical ectodermal ridge morphology ( J:135784 )

• unstratified

small limb buds ( J:135784 )

• limb buds are small and have a pointed shape unlike in wild-type mice

short forelimb ( J:135784 )

• severe forelimb truncation

absent hindlimb ( J:135784 )

Allelic Composition	Trp63^tm1Aam/Trp63⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63^tm1Aam mutation (0 available); any Trp63 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal phalanx morphology ( J:135784 )

• one mouse exhibits mild deviation of the central phalanges

ectrodactyly ( J:135784 )

• only observed in 1 of 40 mice

• mild ectodactyly is rare

skeleton

abnormal phalanx morphology ( J:135784 )

• one mouse exhibits mild deviation of the central phalanges

Allelic Composition	Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi Trp63^tm1Aam/Trp63^tm1Aam
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5/Dlx6^tm1Levi mutation (0 available); any Dlx5 mutation (25 available)
Dlx5^tm1Levi mutation (1 available); any Dlx5 mutation (25 available)
Trp63^tm1Aam mutation (0 available); any Trp63 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal phalanx morphology ( J:135784 )

• mice exhibit dysmorphologies of the most proximal segments of the central phalanges

• in 2 of 3 mice the posterior fingers are missing

ectrodactyly ( J:135784 )

• all mice exhibit severe ectrodactyly in the hindlimbs with two to four fingers missing

monodactyly ( J:135784 )

• in one mouse

syndactyly ( J:135784 )

• in hind- and forelimbs

skeleton

abnormal phalanx morphology ( J:135784 )

• mice exhibit dysmorphologies of the most proximal segments of the central phalanges

• in 2 of 3 mice the posterior fingers are missing

Allelic Composition	Trp63^tm1Aam/Trp63^tm1Aam Dlx5^tm1Levi/Dlx5/Dlx6^tm1Levi
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5/Dlx6^tm1Levi mutation (0 available); any Dlx6 mutation (29 available)
Dlx5^tm1Levi mutation (1 available); any Dlx5 mutation (25 available)
Trp63^tm1Aam mutation (0 available); any Trp63 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal phalanx morphology ( J:135784 )

• mice exhibit dysmorphologies of the most proximal segments of the central phalanges

• in 2 of 3 mice the posterior fingers are missing

ectrodactyly ( J:135784 )

• all mice exhibit severe ectrodactyly in the hindlimbs with two to four fingers missing

monodactyly ( J:135784 )

• in one mouse

syndactyly ( J:135784 )

• in hind- and forelimbs

skeleton

abnormal phalanx morphology ( J:135784 )

• mice exhibit dysmorphologies of the most proximal segments of the central phalanges

• in 2 of 3 mice the posterior fingers are missing

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