Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Aam mutation
(0 available);
any
Trp63 mutation
(60 available)
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craniofacial
embryo
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• mice exhibit ectodermal dysplasia
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• limb buds are small and have a pointed shape unlike in wild-type mice
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limbs/digits/tail
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• limb buds are small and have a pointed shape unlike in wild-type mice
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• severe forelimb truncation
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Allelic Composition |
Trp63tm1Aam/Trp63+
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Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Aam mutation
(0 available);
any
Trp63 mutation
(60 available)
|
|
|
limbs/digits/tail
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• one mouse exhibits mild deviation of the central phalanges
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• only observed in 1 of 40 mice
• mild ectodactyly is rare
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skeleton
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• one mouse exhibits mild deviation of the central phalanges
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5/Dlx6tm1Levi mutation
(0 available);
any
Dlx5 mutation
(23 available)
Dlx5tm1Levi mutation
(1 available);
any
Dlx5 mutation
(23 available)
Trp63tm1Aam mutation
(0 available);
any
Trp63 mutation
(60 available)
|
|
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limbs/digits/tail
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• mice exhibit dysmorphologies of the most proximal segments of the central phalanges
• in 2 of 3 mice the posterior fingers are missing
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• all mice exhibit severe ectrodactyly in the hindlimbs with two to four fingers missing
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skeleton
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• mice exhibit dysmorphologies of the most proximal segments of the central phalanges
• in 2 of 3 mice the posterior fingers are missing
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx5/Dlx6tm1Levi mutation
(0 available);
any
Dlx6 mutation
(29 available)
Dlx5tm1Levi mutation
(1 available);
any
Dlx5 mutation
(23 available)
Trp63tm1Aam mutation
(0 available);
any
Trp63 mutation
(60 available)
|
|
|
limbs/digits/tail
|
• mice exhibit dysmorphologies of the most proximal segments of the central phalanges
• in 2 of 3 mice the posterior fingers are missing
|
|
• all mice exhibit severe ectrodactyly in the hindlimbs with two to four fingers missing
|
skeleton
|
• mice exhibit dysmorphologies of the most proximal segments of the central phalanges
• in 2 of 3 mice the posterior fingers are missing
|