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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym
targeted mutation 5, Susan Dymecki
MGI:3795199
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/? 		involves: 129S1/Sv * 129X1/SvJ MGI:3804425
cn2
 		En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Tg(Fev-flpe)1Dym/? 		involves: 129S1/Sv * 129X1/SvJ MGI:3804428
cn3
 		Egr2tm2(cre)Pch/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/? 		involves: 129S2/SvPas MGI:3804426
cn4
 		Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Tg(Hoxa2-cre)1Dym/? 		Not Specified MGI:3804427


Genotype
MGI:3804425
cn1
Allelic
Composition		 En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Fev-flpe)1Dym mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising caudal to r1 are labeled by eGFP




Genotype
MGI:3804428
cn2
Allelic
Composition		 En1tm2(cre)Wrst/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Nkx2-2tm1Jlr/Nkx2-2tm1Jlr
Tg(Fev-flpe)1Dym/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Nkx2-2tm1Jlr mutation (0 available); any Nkx2-2 mutation (14 available)
Tg(Fev-flpe)1Dym mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal rhombomere morphology ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem

embryo
abnormal rhombomere morphology ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the P0.5 brainstem
• rhombomere-1 (r1) derived 5-HT precursor cells are not found in the B1-B3 areas of the brainstem




Genotype
MGI:3804426
cn3
Allelic
Composition		 Egr2tm2(cre)Pch/?
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr2tm2(cre)Pch mutation (2 available); any Egr2 mutation (31 available)
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Fev-flpe)1Dym mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-3 (r3) rhombomere-5 (r5) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r3 or r5 are labeled by eGFP




Genotype
MGI:3804427
cn4
Allelic
Composition		 Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym/?
Tg(Fev-flpe)1Dym/?
Tg(Hoxa2-cre)1Dym/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm5(CAG-EGFP,-lacZ)Dym mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Tg(Fev-flpe)1Dym mutation (0 available)
Tg(Hoxa2-cre)1Dym mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:136096 )
• alleles are used in intersectional and subtractive cell lineage fate mapping to visualize serotonin (5-HT) producing neurons and their precursors in the E12.5 embryonic hindbrain or mature brainstem
• rhombomere-2 (r2) derived 5-HT precursor cells are labeled by beta-gal while 5-HT precursors arising outside of r2 are labeled by eGFP




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory