Analysis Tools
normal phenotype
|
• no abnormalities in T cell development are observed
|
|
Allele Symbol Allele Name Allele ID |
Akt1Gt1Pnt gene trap 1, Philip N Tsichlis MGI:3794786 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no abnormalities in T cell development are observed
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice
|
|
• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice
|
|
• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background
• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background
• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background
• this decreased proliferation rate is not observed in later stages of tumor development
• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background
• parenchymal metastases of breast adenocarcinomas are found in the lung
|
|
• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background
• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background
• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background
• this decreased proliferation rate is not observed in later stages of tumor development
• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background
• parenchymal metastases of breast adenocarcinomas are found in the lung
|
|
• female virgin mice develop mammary tumors by 45 weeks of age which is significantly later than in mice carrying the transgene on a wild-type background
• mice harbor fewer and smaller hyperplastic foci at 8 and 12 weeks of age compared to transgenic mice on a wild-type background
• at later ages, the hyperplastic foci are smaller in size than in the transgenic controls
• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background
• the percentage of proliferative cells found in early lesions of the mammary gland is half that found in transgenic mice on the wild-type background
• this decreased proliferation rate is not observed in later stages of tumor development
• both early lesions and advanced neoplasms have about double the percentage of apoptotic cells than is found in comparable tumors of transgenic mice on a wild-type background
• parenchymal metastases of breast adenocarcinomas are found in the lung
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||