All Phenotypes Tg(Osr1-cre)4Mrt MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Osr1-cre)4Mrt
transgene insertion 4, Gail R Martin
MGI:3793846

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467305
cn2	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467304
cn3	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N	MGI:5467306
cn4	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5467307
cn5	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:6193618
cn6	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor⁺ Tg(Osr1-cre)4Mrt/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N	MGI:6193619

Allelic Composition	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (15 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (15 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:192348 )

• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

reproductive system

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:192348

Allelic Composition	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (15 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (15 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

reproductive system

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

Allelic Composition	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt/0 Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Tg(CAG-Bgeo,-Spry2,-ALPP)1Mrt mutation (1 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 15% of prostate ducts as early as 2 weeks of age, in 31% of ducts at 4 weeks, and 42% of ducts at 9 months of age

Allelic Composition	Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• PIN is seen in 31% of prostate ducts as early as 2 weeks of age, in 66% of ducts at 4 weeks, and 79% of ducts at 9 months of age show extensive high-grade PIN

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

reproductive system

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 5.6% of mice develop prostatic adenocarcinoma after 12 months of age

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 50% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:234601

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-AR)Zsu}/Gt(ROSA)26Sor⁺ Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

increased malignant tumor incidence ( J:234601 )

• malignancy, with vascular invasion by neoplastic cells or local invasion of the tumor beyond the basement membrane into surrounding stromal tissues is seen in some mice

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

reproductive system

increased prostate gland adenocarcinoma incidence ( J:234601 )

• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age

• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

increased prostate intraepithelial neoplasia incidence ( J:234601 )

• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age

• 40.9% of mice exhibit mPIN lesions

• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells

• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate

• foci of atypical cells partially fill the lumen of the ducts

• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate adenocarcinoma		DOID:2526		J:234601

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23