Phenotypes associated with this allele

• Allele Symbol: Tg(Hoxb6-cre/ERT)1Smac
• Allele Name: transgene insertion 1, Susan Mackem
• Allele ID: MGI:3793474
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(Grem1)Svok/Gt(ROSA)26Sor^tm1(Grem1)Svok Tg(Hoxb6-cre/ERT)1Smac/0	involves: 129S1/Sv * FVB/N	MGI:5588431
cn2	Gt(ROSA)26Sor^tm1(Grem1)Svok/Gt(ROSA)26Sor^+ Tg(Hoxb6-cre/ERT)1Smac/0	involves: 129S1/Sv * FVB/N	MGI:5588434

Genotype
MGI:5588431

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor^{tm1(Grem1)Svok}; Tg(Hoxb6-cre/ERT)1Smac/0
• Genetic Background: involves: 129S1/Sv * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:214075 )

• following tamoxifen administration at E11.5, hindlimb digits have nubs (ecotopic pieces of cartilage) (2/2)

• following tamoxifen administration at E10, forelimb digits exhibit nubs (8/8)

• following tamoxifen administration at E10.5 or E11, forelimb digits exhibit nubs (3/3)

• following tamoxifen administration at E11.5, forelimbs develop normally

polyphalangy ( J:214075 )

• following tamoxifen administration at E11, hindlimb digits exhibit multiple distal bifurcations (3/4), but no completely formed extra digits

brachydactyly ( J:214075 )

• following tamoxifen administration at E9.5, forelimbs exhibit digit reduction (3/5)

polydactyly ( J:214075 )

• following tamoxifen administration at E10 and E10.5, hindlimbs have polydactyly

bowed femur ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit bowed femurs and tibia

absent fibula ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit reduced or absent fibula

short fibula ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit reduced or absent fibula

bowed tibia ( J:214075 )

• ollowing tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit bowed femurs and tibia

absent hindlimb ( J:214075 )

• following tamoxifen administration at E9.5, hindlimbs are almost absent and contain only a few digit-like elements in 3/5 embryos

skeleton

polyphalangy ( J:214075 )

• following tamoxifen administration at E11, hindlimb digits exhibit multiple distal bifurcations (3/4), but no completely formed extra digits

bowed femur ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit bowed femurs and tibia

absent fibula ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit reduced or absent fibula

short fibula ( J:214075 )

• following tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit reduced or absent fibula

bowed tibia ( J:214075 )

• ollowing tamoxifen administration at E10 (5/8) and E10.5(2/3) some embryos exhibit bowed femurs and tibia

Genotype
MGI:5588434

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Grem1)Svok}/Gt(ROSA)26Sor⁺; Tg(Hoxb6-cre/ERT)1Smac/0
• Genetic Background: involves: 129S1/Sv * FVB/N

limbs/digits/tail

abnormal digit morphology ( J:214075 )

• following tamoxifen administration at E10, hindlimb digits (1/1) are nubs (ectopic pieces of cartilage)

• following tamoxifen administration at E11.5, hindlimb digits have nubs (2/2), but nubs are smaller than nubs observed at earlier time points

• following tamoxifen administration at E10, E10.5 and E11, forelimb digits exhibit nubs

• following tamoxifen administration at E11.5, forelimbs develop normally

polyphalangy ( J:214075 )

• following tamoxifen administration at E11, hindlimb digits exhibit distal bifurcation (1/6) or have nubs (5/6)

brachydactyly ( J:214075 )

• following tamoxifen administration at E9.5, forelimb digits exhibit digit reduction (1/3)

polydactyly ( J:214075 )

• following tamoxifen administration at E10.5, hindlimb digits exhibit polydactyly (3/6), exhibit distal bifurcation (1/6) or have nubs (2/6)

absent hindlimb ( J:214075 )

• following tamoxifen administration at E9.5, some embryos have no hindlimbs (1/4)

skeleton

polyphalangy ( J:214075 )

• following tamoxifen administration at E11, hindlimb digits exhibit distal bifurcation (1/6) or have nubs (5/6)