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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxnb1tm1.1Ltam
targeted mutation 1.1, Luca Tamagnone
MGI:3790773
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam involves: 129S1/Sv * C57BL/6 MGI:3805512
cx2
 		Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811331
cx3
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811335
cx4
 		Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2tm1Matl 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811340
cx5
 		Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2tm1Matl 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:5811341


Genotype
MGI:3805512
hm1
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (107 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
enlarged kidney ( J:168399 )
• at E13.5, kidneys are larger than those in heterozygous controls
• however, no differences in size are detected at E11.5 and E12.5
abnormal branching involved in ureteric bud morphogenesis ( J:168399 )
• at E13.5, kidneys exhibit more ureteric branches than those in heterozygous controls
• however, no differences in developmental stage are detected at E11.5 and E12.5

normal phenotype
no abnormal phenotype detected ( J:134426 )
• viable and fertile, no defects in development, or in adult histology and basic functional parameters

growth/size/body
enlarged kidney ( J:168399 )
• at E13.5, kidneys are larger than those in heterozygous controls
• however, no differences in size are detected at E11.5 and E12.5




Genotype
MGI:5811331
cx2
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (107 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:168399 )
N
• mice are viable

reproductive system
reduced fertility ( J:168399 )
• mice are able to produce offspring although litters are very small




Genotype
MGI:5811335
cx3
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (107 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:168399 )
N
• mice are viable

reproductive system
reduced fertility ( J:168399 )
• mice are able to produce offspring although litters are very small




Genotype
MGI:5811340
cx4
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1+
Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (107 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5811341
cx5
Allelic
Composition		 Plxnb1tm1.1Ltam/Plxnb1tm1.1Ltam
Plxnb2tm1Matl/Plxnb2tm1Matl
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnb1tm1.1Ltam mutation (2 available); any Plxnb1 mutation (107 available)
Plxnb2tm1Matl mutation (2 available); any Plxnb2 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality ( J:168399 )
• double homozygotes show high embryonic lethality prior to onset of nephrogenesis
• only 1 of 19 double homozygotes survived to E12.5

renal/urinary system
renal hypoplasia ( J:168399 )
• the single double homozygous embryo surviving to E12 showed hypoplastic kidneys with ureteric branches and differentiating mesenchyme
abnormal ureteric bud trunk morphology ( J:168399 )
• at E12, the ureteric stalks appear to be longer than in double heterozygotes




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory