All Phenotypes Bdkrb1<tm2Bdr> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bdkrb1^tm2Bdr
targeted mutation 2, Michael Bader
MGI:3790746

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Bdkrb1^tm2Bdr/Bdkrb1^tm2Bdr Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh	involves: 129S7/SvEvBrd * C57BL/6	MGI:3797826

Allelic Composition	Bdkrb1^tm2Bdr/Bdkrb1^tm2Bdr Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdkrb1^tm2Bdr mutation (0 available); any Bdkrb1 mutation (21 available)
Bdkrb2^tm1Jfh mutation (3 available); any Bdkrb2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:135789 )

• several tissues (stomach, ileum, urinary bladder, uterus, aorta and portal vein) fail to exhibit contractile response to treatment with DABK and BK unlike wild-type mice

cardiovascular system

cardiovascular system phenotype ( J:135789 )

N	• blood pressure and cardiac morphology are normal

decreased heart rate ( J:135789 )

immune system

decreased susceptibility to endotoxin shock ( J:135789 )

• mice exhibit no hypotensive response to LPS unlike wild-type mice

• however, survival is the same as in wild-type mice following treatment with LPS

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23