Phenotypes associated with this allele

• Allele Symbol: Gpam^tm1.1Dali
• Allele Name: targeted mutation 1.1, Daniel Linden
• Allele ID: MGI:3785384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpam^tm1.1Dali/Gpam^tm1.1Dali	involves: 129S1/Sv * 129X1/SvJ	MGI:3795720

Genotype
MGI:3795720

hm1

• Allelic Composition: Gpam^tm1.1Dali/Gpam^tm1.1Dali
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

slow postnatal weight gain ( J:134068 )

• female mice gain weight slower on a chow diet resulting in significantly less body weight compared to controls by 18 weeks of age

• differences in body weight do not occur if mice were fed a high fat diet

adipose tissue

decreased gonadal fat pad weight ( J:134068 )

• female mice have reduced weights of ovarian white fat pads compared to wild-type controls

• there are no differences in fat pad weights when mice are fed a high fat diet

decreased retroperitoneal fat pad weight ( J:134068 )

• female mice have reduced weights of retroperitoneal white fat pads compared to wild-type controls

• there are no differences in fat pad weights when mice are fed a high fat diet

decreased percent body fat/body weight ( J:134068 )

• female mice fed a chow diet have 27% less total body fat at 21 weeks of age

• there is no differences in body fat when mice are fed a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:134068 )

• triacylglycerol content is reduced in the liver of chow fed mice but not in the livers of mice fed a high fat diet

abnormal hepatocyte morphology ( J:134068 )

• decreased intracellular droplet size is observed in chow-fed females compared to wild-type controls

abnormal liver physiology ( J:134068 )

• there is a 15% decrease in fatty acid oxidation in female mice fed a chow diet compared to wild-type controls

homeostasis/metabolism

increased circulating ketone body level ( J:134068 )

• plasma beta-hydroxybutyrate levels are increased 3-fold in female mice fed a chow diet

• beta-hydroxybutyrate levels are increased by only 59% when female mice are fed a high fat diet

• beta-hydroxybutyrate levels are increased by 47% in chow-fed male mice and are not significantly different when fed a high fat diet

decreased circulating cholesterol level ( J:134068 )

• female mice fed a chow diet have reduced mean cholesterol levels in their plasma compared to wild-type mice (1.92mM vs. 2.24mM in controls)

• there are no differences when mice are fed a high fat diet

decreased circulating triglyceride level ( J:134068 )

• female mice fed a chow diet have reduced mean triacylglycerol levels in their plasma compared to wild-type mice (0.37mM vs. 0.59mM in controls)

• there are no differences when mice are fed a high fat diet

insulin resistance ( J:134068 )

• female mice have an increased insulin resistance after being fed a high fat diet for 12 weeks

decreased liver triglyceride level ( J:134068 )

• triacylglycerol content is reduced in the liver of chow fed mice but not in the livers of mice fed a high fat diet