Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pscatm1Witt mutation
(1 available);
any
Psca mutation
(12 available)
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normal phenotype
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• mice are viable, fertile, and aged mice develop tumors at the same rate as control mice
• extensive analysis revealed no difference in the size, structure, and regenerative capabilities of the prostrate
• there are no significant increases in prostrate adenocarcinomas or primary epithelial tumors after sub-lethal gamma irradiation compared to control mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pscatm1Witt mutation
(1 available);
any
Psca mutation
(12 available)
Tg(TRAMP)8247Ng mutation
(1 available)
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neoplasm
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• mice are moribund with prostrate tumors on average at 28.6 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)
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endocrine/exocrine glands
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• mice are moribund with prostrate tumors on average at 28.6 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)
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reproductive system
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• mice are moribund with prostrate tumors on average at 28.6 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene (56.5% compared to 33%)
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pscatm1Witt mutation
(1 available);
any
Psca mutation
(12 available)
Tg(TRAMP)8247Ng mutation
(1 available)
|
|
|
neoplasm
|
|
• mice are moribund with prostrate tumors on average at 34.4 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene
|
reproductive system
|
|
• mice are moribund with prostrate tumors on average at 34.4 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene
|
endocrine/exocrine glands
|
|
• mice are moribund with prostrate tumors on average at 34.4 weeks of age
• intraepithelial neoplasia and adenocarcinomas at different stages of differentiation are observed in the prostrate
• there is a increased incidence of metastasis compared to mice that carry just the transgene
|
Analysis Tools