Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galk1tm1Stb mutation
(1 available);
any
Galk1 mutation
(7 available)
Tg(Cryaa-AKR1B1)222Smch mutation
(0 available)
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vision/eye
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• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation
(0 available);
any
Sord mutation
(19 available)
Tg(Cryaa-AKR1B1)222Smch mutation
(0 available)
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vision/eye
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• mice injected with streptozotocin are susceptible to diabetic cataract formation, while non-transgenic SorD-deficient mice do not develop cataracts
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SordC57BL/Lia mutation
(0 available);
any
Sord mutation
(19 available)
Tg(Cryaa-AKR1B1)222Smch mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
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• mice injected with streptozotocin are susceptible to diabetic cataract formation more, but not as rapidly as galactosemic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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vision/eye
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• mice induced to become diabetic with streptozotocin injection do not develop cataracts
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• 3-week old mice fed a 50% galactose diet, cataracts develop in transgenic animals, but not in non-transgenic mice; stages of cataract development reached correlates with level of transgene expression
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homeostasis/metabolism
Analysis Tools