Galk1^tm1Stb
Targeted Allele Detail

Summary

• Symbol: Galk1^tm1Stb
• Name: galactokinase 1; targeted mutation 1, Dwight Stambolian
• MGI ID: MGI:2148688
• Synonyms: GK
• Gene: Galk1 Location: Chr11:115899283-115903545 bp, - strand Genetic Position: Chr11, 80.91 cM
• Alliance: Galk1^tm1Stb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63743
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of exons 3, 4 and 5 with a neomycin cassette. No galactokinase activity could be detected in liver extracts of homozyogous mice. (J:63743)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Galk1 Mutation: 7 strains or lines available

References

• Original: J:63743 Ai Y, et al., A mouse model of galactose-induced cataracts. Hum Mol Genet. 2000 Jul 22;9(12):1821-7
• All: 1 reference(s)