All Phenotypes Gt(ROSA)26Sor<tm1(Tfrc*)Nca> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}
targeted mutation 1, Nancy C Andrews
MGI:3778905

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gt(ROSA)26Sor^{tm1(Tfrc)Nca}/Gt(ROSA)26Sor^{tm1(Tfrc)Nca}	involves: 129S4/SvJae * FVB/N	MGI:3783642
cn2	Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}/Gt(ROSA)26Sor⁺ Tfrc^tm3.1Nca/Tfrc^tm3.1Nca Tg(Vil1-cre)20Syr/0	involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2	MGI:5689324
cx3	Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}/Gt(ROSA)26Sor⁺ Hfe^tm2Nca/Hfe^tm2Nca	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N	MGI:3783643

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tfrc)Nca}/Gt(ROSA)26Sor^{tm1(Tfrc)Nca}
Genetic Background	involves: 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tfrc*)Nca} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased heart iron level ( J:133221 )

• at 8 weeks of age significant iron loading is seen in the heart unlike wild-type mice or mice homozygous for Hfe^tm2Nca

increased circulating iron level ( J:133221 )

• significant increase in occupancy of serum transferrin with iron without any decrease in iron use for erythropoiesis

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels, although this increase is less than that in Hfe^tm2Nca

• deposition of iron is predominantly periportal

cardiovascular system

increased heart iron level ( J:133221 )

• at 8 weeks of age significant iron loading is seen in the heart unlike wild-type mice or mice homozygous for Hfe^tm2Nca

liver/biliary system

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels, although this increase is less than that in Hfe^tm2Nca

• deposition of iron is predominantly periportal

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}/Gt(ROSA)26Sor⁺ Tfrc^tm3.1Nca/Tfrc^tm3.1Nca Tg(Vil1-cre)20Syr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * CD-1 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tfrc*)Nca} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Tfrc^tm3.1Nca mutation (2 available); any Tfrc mutation (61 available)
Tg(Vil1-cre)20Syr mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:224823 )

• some mice die postnatally

• however, most mice are alive at 2 months

digestive/alimentary system

abnormal digestive system morphology ( J:224823 )

• mice that die exhibit the same phenotype as Tfrc^tm3.1Nca/Tfrc^tm3.1Nca Tg(Vil-cre)20Syr mice

• however, mice that survive at 2 months exhibit normal architecture and proliferation of crypt intestinal epithelial cells

Allelic Composition	Gt(ROSA)26Sor^{tm1(Tfrc*)Nca}/Gt(ROSA)26Sor⁺ Hfe^tm2Nca/Hfe^tm2Nca
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Tfrc*)Nca} mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Hfe^tm2Nca mutation (1 available); any Hfe mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating iron level ( J:133221 )

• significant increase in occupancy of serum transferrin with iron

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels

• this increase is intermediate between that of mice homozygous for Hfe^tm2Nca or Gt(ROSA)26Sor^{tm1(Tfrc*)Nca} alone

• deposition of iron is predominantly periportal

liver/biliary system

increased liver iron level ( J:133221 )

• increase in liver non-heme iron levels

• this increase is intermediate between that of mice homozygous for Hfe^tm2Nca or Gt(ROSA)26Sor^{tm1(Tfrc*)Nca} alone

• deposition of iron is predominantly periportal

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