Analysis Tools
immune system
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• the calcineurin-dependent block in delivery of phagosomal contents to lysosomes is absent in these animals
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• there are reduced number of CD19-positive B cells in the blood and lymph nodes but normal numbers in the spleen
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• nave CD4 T cells are deleted in the periphery with virtually no cells in the blood and lymph nodes and severely reduced numbers in the spleen
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• nave CD8 T cells are deleted in the periphery with virtually no cells in the blood and lymph nodes and severely reduced numbers in the spleen
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• there is a slight reduction of CD11b-positive monocytes in the blood and lymph nodes
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• T cells do not flux calcium when stimulated through their TCR
• lack of calcium flux results from defective production of inositol-1,4,5-trisphosphate upon TCR triggering
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• splenic T cells fail to proliferate in response to allogenic stimulation or anti-CD3 + anti-CD28 activation
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• single-positive thymocytes but not double-positive have defects in TCR-mediated calcium flux
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• splenic T cells fail to secrete IL-2 in response to activators
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• macrophages infected with M. bovis are able to kill the mycobacteria after phagocytosis by transfering them to lysosomes while wild-type macrophages are unable to kill the mycobacteria because they take up residence within the phagosomes
• M. Bovis fails to survive or proliferate 48 hours after culture with macrophages compared to M. Bovis cultured with wild-type macrophages that proliferate robustly 48 hours later
• M. tuberculosis are found in liver lysosomal compartments in mice one week after infection instead of liver phagosomal compartments as occurs in wild-type mice
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hematopoietic system
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• the calcineurin-dependent block in delivery of phagosomal contents to lysosomes is absent in these animals
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• there are reduced number of CD19-positive B cells in the blood and lymph nodes but normal numbers in the spleen
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• nave CD4 T cells are deleted in the periphery with virtually no cells in the blood and lymph nodes and severely reduced numbers in the spleen
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• nave CD8 T cells are deleted in the periphery with virtually no cells in the blood and lymph nodes and severely reduced numbers in the spleen
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• there is a slight reduction of CD11b-positive monocytes in the blood and lymph nodes
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• T cells do not flux calcium when stimulated through their TCR
• lack of calcium flux results from defective production of inositol-1,4,5-trisphosphate upon TCR triggering
|
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• splenic T cells fail to proliferate in response to allogenic stimulation or anti-CD3 + anti-CD28 activation
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• single-positive thymocytes but not double-positive have defects in TCR-mediated calcium flux
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endocrine/exocrine glands
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• single-positive thymocytes but not double-positive have defects in TCR-mediated calcium flux
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cellular
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• splenic T cells fail to proliferate in response to allogenic stimulation or anti-CD3 + anti-CD28 activation
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• the calcineurin-dependent block in delivery of phagosomal contents to lysosomes is absent in these animals
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