Coro1a^tm1Jpie
Targeted Allele Detail

Summary

• Symbol: Coro1a^tm1Jpie
• Name: coronin, actin binding protein 1A; targeted mutation 1, Jean Pieters
• MGI ID: MGI:3778894
• Synonyms: Cor1^-, Coronin 1 ^-
• Gene: Coro1a Location: Chr7:126298946-126303925 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F3
• Alliance: Coro1a^tm1Jpie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:133404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains the transcriptional start site, was replaced by an eGFP reporter and neomycin resistance cassette. Gene inactivation was confirmed by an absence of protein in bone marrow derived macrophages as determined by immunoblotting and immunohistochemistry. Minimal GFP expression was detected in the macrophages. (J:133404)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Coro1a Mutation: 24 strains or lines available

References

• Original: J:133404 Jayachandran R, et al., Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell. 2007 Jul 13;130(1):37-50
• All: 16 reference(s)