All Phenotypes Nfkbid<tm1Clay> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfkbid^tm1Clay/Nfkbid^tm1Clay	involves: 129S6/SvEvTac * C57BL/6	MGI:3777766
cx2	H2^b/H2^b Nfkbid^tm1Clay/Nfkbid^tm1Clay Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6	MGI:3777767

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:132071 )

• Both CD4- and CD8- T cells proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

• T cells also have reduced proliferation in response to allogenic MHC

• proliferation defects are intrinsic to T cells as revealed by bone marrow chimeras

• T cells proliferate normally to PMA + ionomycin treatment

abnormal thymocyte activation ( J:132071 )

• thymoyctes proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

abnormal NK cell physiology ( J:132071 )

• NK cells produce very little IFN-gamma when stimulated in culture

decreased interferon-gamma secretion ( J:132071 )

• thymocytes secrete 2- to 3- fold less IFN-gamma when stimulated in vitro

• CD8 T cells produce very little IFN-gamma when stimulated in vitro CD8 T cells produce very little IFN-gamma when stimulated in vitro

decreased interleukin-2 secretion ( J:132071 )

• thymocytes secrete 2- to 3- fold less IL-2 when stimulated in vitro

• CD8 T cells produce virtually no IL-2 when stimulated in vitro

hematopoietic system

decreased T cell proliferation ( J:132071 )

• Both CD4- and CD8- T cells proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

• T cells also have reduced proliferation in response to allogenic MHC

• proliferation defects are intrinsic to T cells as revealed by bone marrow chimeras

• T cells proliferate normally to PMA + ionomycin treatment

abnormal thymocyte activation ( J:132071 )

• thymoyctes proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

abnormal NK cell physiology ( J:132071 )

• NK cells produce very little IFN-gamma when stimulated in culture

endocrine/exocrine glands

abnormal thymocyte activation ( J:132071 )

• thymoyctes proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

cellular

decreased T cell proliferation ( J:132071 )

• Both CD4- and CD8- T cells proliferate poorly in culture to ConA, anti-CD3 treatment, or anti-CD3 + anti-CD28 treatment

• T cells also have reduced proliferation in response to allogenic MHC

• proliferation defects are intrinsic to T cells as revealed by bone marrow chimeras

• T cells proliferate normally to PMA + ionomycin treatment

Allelic Composition	H2^b/H2^b Nfkbid^tm1Clay/Nfkbid^tm1Clay Rag2^tm1Fwa/Rag2^tm1Fwa Tg(TcraN15,TcrbN15)L2Elre/?
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2^b mutation (28 available); any H2 mutation (280 available)
Nfkbid^tm1Clay mutation (2 available); any Nfkbid mutation (22 available)
Rag2^tm1Fwa mutation (48 available); any Rag2 mutation (117 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

decreased interleukin-2 secretion ( J:132071 )

• lymph node T cells secrete significantly less IL-2 than wild-type T cells in response to irradiated spleen cells loaded with VSV8 antigen

hematopoietic system

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

endocrine/exocrine glands

abnormal thymocyte activation ( J:132071 )

• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

cellular

decreased T cell proliferation ( J:132071 )

• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen

• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23