All Phenotypes Nanos3<tm2(cre)Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nanos3^tm2(cre)Ysa
targeted mutation 2, Yumiko Saga
MGI:3777592

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Nanos3^tm2(cre)Ysa/Nanos3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:6358666
cn2	Ctnnb1^tm2Kem/Ctnnb1⁺ Nanos3^tm2(cre)Ysa/Nanos3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	MGI:6358667
cn3	Ctnnb1^tm1Mmt/Ctnnb1⁺ Nanos3^tm2(cre)Ysa/Nanos3⁺	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:6358659
cn4	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Nanos3^tm2(cre)Ysa/Nanos3⁺	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	MGI:6358660
cn5	Nanos3^tm2(cre)Ysa/Nanos3⁺ Tg(CAG-cat,-Nanos2)1Ysa/0	Not Specified	MGI:3778829

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Nanos3^tm2(cre)Ysa/Nanos3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm2Kem mutation (1 available); any Ctnnb1 mutation (49 available)
Nanos3^tm2(cre)Ysa mutation (2 available); any Nanos3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal spermatogonia morphology ( J:257319 )

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

reproductive system

abnormal spermatogonia morphology ( J:257319 )

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

Allelic Composition	Ctnnb1^tm2Kem/Ctnnb1⁺ Nanos3^tm2(cre)Ysa/Nanos3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal spermatogonia morphology ( J:257319 )

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

reproductive system

abnormal spermatogonia morphology ( J:257319 )

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• reduced number of Rarg+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1⁺ Nanos3^tm2(cre)Ysa/Nanos3⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1^tm1Mmt mutation (0 available); any Ctnnb1 mutation (49 available)
Nanos3^tm2(cre)Ysa mutation (2 available); any Nanos3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal spermatogonia morphology ( J:257319 )

• normal number of Rarg+ undifferentiated spermatogonia in tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• normal number of Rarg+ undifferentiated spermatogonia in tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

reproductive system

abnormal spermatogonia morphology ( J:257319 )

• normal number of Rarg+ undifferentiated spermatogonia in tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• normal number of Rarg+ undifferentiated spermatogonia in tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

Allelic Composition	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Nanos3^tm2(cre)Ysa/Nanos3⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal spermatogonia morphology ( J:257319 )

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

reproductive system

abnormal spermatogonia morphology ( J:257319 )

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

abnormal seminiferous tubule morphology ( J:257319 )

• significantly increased frequency of defective tubules (with lost or exiguous germ cell layer(s))

• significantly increased frequency of Sertoli cell only tubules

• significantly reduced number of Gfra1+ undifferentiated spermatogonia in tubules

decreased testis weight ( J:257319 )

Allelic Composition	Nanos3^tm2(cre)Ysa/Nanos3⁺ Tg(CAG-cat,-Nanos2)1Ysa/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nanos3^tm2(cre)Ysa mutation (2 available); any Nanos3 mutation (28 available)
Tg(CAG-cat,-Nanos2)1Ysa mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal female germ cell morphology ( J:132711 )

• meiosis is inhibited in female germ cells and these cells undergo male-type differentiation

abnormal female meiosis ( J:132711 )

• meiosis is inhibited in female germ cells

cellular

abnormal female germ cell morphology ( J:132711 )

• meiosis is inhibited in female germ cells and these cells undergo male-type differentiation

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