Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation
(0 available);
any
Hdac6 mutation
(14 available)
|
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immune system
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• from peritoneal elicited macrophages (PEM) and dendritic cells in response to LPS
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation
(0 available);
any
Hdac6 mutation
(14 available)
|
|
|
reproductive system
N |
• mice are fertile and exhibit normal fertilization
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immune system
N |
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
|
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• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
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• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
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skeleton
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• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
|
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• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal
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growth/size/body
nervous system
N |
• mice exhibit normal brain and spinal cord morphology
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hematopoietic system
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• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|
|
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation
(0 available);
any
Hdac6 mutation
(14 available)
Tg(SOD1*G93A)1Gur mutation
(4 available)
|
|
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mortality/aging
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• modest increase in survival compared with Tg(SOD1*G93A)1Gur mice
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nervous system
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• NMJ innervation of the gastrocnemius muscle is improved compared to in Tg(SOD1*G93A)1Gur mice
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• in the ventral horn compared to in Tg(SOD1*G93A)1Gur mice with more pronounced protection of large neurons
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• mice exhibit higher compound action potential amplitudes compared with Tg(SOD1*G93A)1Gur mice
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behavior/neurological
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• same age of onset as in Tg(SOD1*G93A)1Gur mice
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Allelic Composition |
Hdac6tm1.1Pmt/Y
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|
Genetic Background |
involves: 129P2/OlaHsd * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation
(0 available);
any
Hdac6 mutation
(14 available)
|
|
|
reproductive system
N |
• mice are fertile and exhibit normal fertilization
|
immune system
N |
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
|
|
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|
|
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|
skeleton
|
• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
|
|
• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal
|
growth/size/body
nervous system
N |
• mice exhibit normal brain and spinal cord morphology
|
hematopoietic system
|
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|
|
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
|