Phenotypes associated with this allele

• Allele Symbol: Del(2Hoxd4-Hoxd11)36Ddu
• Allele Name: deletion, Chr 2, Denis Duboule 36
• Allele ID: MGI:3776052
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(2Hoxd4-Hoxd11)36Ddu/Del(2Hoxd4-Hoxd11)36Ddu	Not Specified	MGI:3810771
ht2	Del(2Hoxd4-Hoxd11)36Ddu/+	Not Specified	MGI:3810773

Genotype
MGI:3810771

hm1

• Allelic Composition: Del(2Hoxd4-Hoxd11)36Ddu/Del(2Hoxd4-Hoxd11)36Ddu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:131874 )

• all mice die shortly after birth

renal/urinary system

increased kidney apoptosis ( J:131874 )

• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice

increased renal tubule apoptosis ( J:131874 )

• increased apoptosis in the microcystic renal tubules

polycystic kidney ( J:131874 )

decreased kidney collecting duct number ( J:131874 )

• reduced number

abnormal kidney cortex morphology ( J:131874 )

• the cortical volume is reduced compared to in wild-type mice

abnormal renal glomerulus morphology ( J:131874 )

• the density of glomeruli is decreased compared to in wild-type mice

abnormal kidney medulla morphology ( J:131874 )

• the medullar volume is reduced compared to in wild-type mice

small kidney ( J:131874 )

• strong reduction in size

renal hypoplasia ( J:131874 )

abnormal renal tubule morphology ( J:131874 )

• tubules exhibit microcystic changes such as thin epithelial cells and the lumina is widened compared to in wild-type mice

dilated renal tubule ( J:131874 )

impaired branching involved in ureteric bud morphogenesis ( J:131874 )

• reduced

cellular

increased kidney apoptosis ( J:131874 )

• mice exhibit increased apoptosis in the kidney, specifically in the cortical interstitium and microcystic tubules, compared to in wild-type mice

increased renal tubule apoptosis ( J:131874 )

• increased apoptosis in the microcystic renal tubules

growth/size/body

polycystic kidney ( J:131874 )

Genotype
MGI:3810773

ht2

• Allelic Composition: Del(2Hoxd4-Hoxd11)36Ddu/+
• Genetic Background: Not Specified

renal/urinary system

dilated renal tubule ( J:131874 )

• in some mice