Analysis Tools
normal phenotype
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• mice are indistinguishable from wild-type mice
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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(ptxA)Cgh targeted mutation 1, Shaun R Coughlin MGI:3776029 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are indistinguishable from wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance
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• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance
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• observed with around 83% frequency in viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• glucose clearance is increased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• unlike in wild-type mice, glucose and insulin levels are unresponsive to treatment with 3-iodothyronamine
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• plasma insulin levels are 4- to 5-fold higher than in wild-type mice
• plasma insulin levels following administration of glucose increased 6.5-fold over basal levels compared to an increase of only 3-fold in similarly treated wild-type mice and peak insulin level achieved is 15-fold higher than in similarly treated wild-type mice
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• glucose clearance is increased compared to in wild-type mice
• when fed a high fat diet, mice exhibit improved glucose tolerance and normal fasting blood glucose levels compared to wild-type mice
• unlike wild-type mice, treatment with SLIGRL does not alter plasma glucose levels
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| N |
• despite altered glucose homeostasis, mice exhibit normal pancreatic islet cell size, number, histological appearance and cellular composition
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen
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• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen
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• observed with 10% frequency in viable embryos collected at 14.5 days post coitus
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• observed in about 40% of embryos collected at 14.5 days post coitus
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• observed in about 40% of embryos collected at 14.5 days post coitus
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• observed with 20% frequency at 14.5 days post coitus; no embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• observed in about 18% of viable embryos collected at 14.5 days post coitus
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• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus
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• observed in about 18% of viable embryos collected at 14.5 days post coitus
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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