About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(ptxA)Cgh
targeted mutation 1, Shaun R Coughlin
MGI:3776029
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh involves: 129P2/OlaHsd * C57BL/6 MGI:3784870
cn2
 		Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Rac1tm1Djk/Rac1tm1Djk 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:4438086
cn3
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784869
cn4
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3784868
cn5
 		Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4431053
cn6
 		Gnaztm1Lfb/Gnaztm1Lfb
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4438084
cn7
 		Gnaztm1Lfb/Gnaz+
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4438085


Genotype
MGI:3784870
hm1
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130781 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:4438086
cn2
Allelic
Composition		 Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Rac1tm1Djk/Rac1tm1Djk
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Rac1tm1Djk mutation (1 available); any Rac1 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:157446 )
• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance

nervous system
spina bifida ( J:157446 )
• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance
exencephaly ( J:157446 )
• observed with around 83% frequency in viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance




Genotype
MGI:3784869
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
improved glucose tolerance ( J:130781 )
• glucose clearance is increased compared to in wild-type mice




Genotype
MGI:3784868
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Ins2-cre)25Mgn mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal glucose homeostasis ( J:130781 )
• unlike in wild-type mice, glucose and insulin levels are unresponsive to treatment with 3-iodothyronamine
increased circulating insulin level ( J:130781 )
• plasma insulin levels are 4- to 5-fold higher than in wild-type mice
• plasma insulin levels following administration of glucose increased 6.5-fold over basal levels compared to an increase of only 3-fold in similarly treated wild-type mice and peak insulin level achieved is 15-fold higher than in similarly treated wild-type mice
improved glucose tolerance ( J:130781 )
• glucose clearance is increased compared to in wild-type mice
• when fed a high fat diet, mice exhibit improved glucose tolerance and normal fasting blood glucose levels compared to wild-type mice
• unlike wild-type mice, treatment with SLIGRL does not alter plasma glucose levels

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:130781 )
N
• despite altered glucose homeostasis, mice exhibit normal pancreatic islet cell size, number, histological appearance and cellular composition




Genotype
MGI:4431053
cn5
Allelic
Composition		 Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

nervous system
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen
exencephaly ( J:157446 )
• observed with 10% frequency in viable embryos collected at 14.5 days post coitus




Genotype
MGI:4438084
cn6
Allelic
Composition		 Gnaztm1Lfb/Gnaztm1Lfb
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaztm1Lfb mutation (1 available); any Gnaz mutation (16 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:157446 )
• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system
spina bifida ( J:157446 )
• observed in about 40% of embryos collected at 14.5 days post coitus
exencephaly ( J:157446 )
• observed with 20% frequency at 14.5 days post coitus; no embryos




Genotype
MGI:4438085
cn7
Allelic
Composition		 Gnaztm1Lfb/Gnaz+
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaztm1Lfb mutation (1 available); any Gnaz mutation (16 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:157446 )
• observed in about 18% of viable embryos collected at 14.5 days post coitus
exencephaly ( J:157446 )
• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo
spina bifida ( J:157446 )
• observed in about 18% of viable embryos collected at 14.5 days post coitus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory