All Phenotypes Shh<tm6Amc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shh^tm6Amc
targeted mutation 6, Andrew P McMahon
MGI:3775846

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shh^tm6Amc/Shh^tm6Amc	Not Specified	MGI:3783756
cx2	Ptch1^tm1Mps/Ptch1⁺ Shh^tm6Amc/Shh^tm6Amc	involves: 129S1/Sv * 129X1/SvJ	MGI:3783757

Allelic Composition	Shh^tm6Amc/Shh^tm6Amc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shh^tm6Amc mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:132152 )

• homozygous mice are still born and show defects consistent with reduced Shh signaling

• neural tube at E10.5 show all Shh-dependent neural progenitor domains resulting in normal induction of floor plate

Allelic Composition	Ptch1^tm1Mps/Ptch1⁺ Shh^tm6Amc/Shh^tm6Amc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1^tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Shh^tm6Amc mutation (1 available); any Shh mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132152 )

• significantly normalized the size of each neural progenitor domains and the gross phenotype of Shh^tm6Amc/Shh^tm6Amc homozygous mice

• authors did not mention whether the prenatal lethality phenotype found in Shh^tm6Amc/Shh^tm6Amc homozygous mice was rescued or not

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