Phenotypes associated with this allele

• Allele Symbol: Crip2^tm1.1Acsc
• Allele Name: targeted mutation 1.1, Achim Schmidtko
• Allele ID: MGI:3775195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crip2^tm1.1Acsc/Crip2^tm1.1Acsc	involves: 129	MGI:3776670

Genotype
MGI:3776670

hm1

• Allelic Composition: Crip2^tm1.1Acsc/Crip2^tm1.1Acsc
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:131957 )

• high doses of cGMP analogs fail to induce mechanical allodynia

• however, low doses of cGMP analogs do induce antinociception in both mutant and wild-type mice

abnormal nociception after inflammation ( J:131957 )

• increase in sensitivity in the second (10 - 60 min) and third (61-120 min) phases of the response to formalin injection

• increase in mechanical hyperalgesia following injection of either zymosan or complete Freud's adjuvant in the hindpaw

nervous system

nervous system phenotype ( J:131957 )

N • despite expression in the spinal cord and dorsal root ganglia no defects are detected in the size or morphology of these structures and the distribution of nociceptive and thermoreceptive primary afferents in the superficial dorsal horn is normal