All Phenotypes Eomes<tm1.1Rob> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eomes^tm1.1Rob/Eomes^tm1.1Rob	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775736
cn2	Eomes^tm1Rob/Eomes^tm1.1Rob Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA	MGI:3775735
cn3	Eomes^tm1Rob/Eomes^tm1.1Rob Tg(T-cre)1Lwd/0	involves: 129S/SvEv * C3H * C57BL/6 * CBA	MGI:3775734
cn4	Eomes^tm1Rob/Eomes^tm1.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775733
cx5	Eomes^tm1.1Rob/Eomes⁺ Wnt3^tm1Brd/Wnt3⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3775738
cx6	Eomes^tm1.1Rob/Eomes⁺ Nodal^tm1Rob/Nodal⁺	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3775732
cx7	Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob	involves: 129S/SvEv * C57BL/6 * CBA	MGI:3775739

Allelic Composition	Eomes^tm1.1Rob/Eomes^tm1.1Rob
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:131055 )

• no embryos are recovered at E7.5

embryo

abnormal trophoblast layer morphology ( J:131055 )

• E7.5 blastocysts after 72 hours in culture either fail to form a a trophoblast outgrowth, or at best, form a rudimentary outgrowth with a few trophoblast giant cells; thus recapitulating the null phenotype

Allelic Composition	Eomes^tm1Rob/Eomes^tm1.1Rob Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)
Eomes^tm1Rob mutation (0 available); any Eomes mutation (41 available)
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal endoderm development ( J:131055 )

• specification of the definitive endoderm is disrupted

abnormal visceral endoderm morphology ( J:131055 )

• visceral endoderm fails to displace proximally at E7.5

Allelic Composition	Eomes^tm1Rob/Eomes^tm1.1Rob Tg(T-cre)1Lwd/0
Genetic Background	involves: 129S/SvEv * C3H * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)
Eomes^tm1Rob mutation (0 available); any Eomes mutation (41 available)
Tg(T-cre)1Lwd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:131055 )

N	• Mendelian numbers of conditionally null embryos are recovered around E6.5

Allelic Composition	Eomes^tm1Rob/Eomes^tm1.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal embryonic epiblast morphology ( J:131055 )

• by late headfold stages, embryos have multiple cystic epiblast invaginations and completely lack a discrete mesoderm layer

absent mesoderm ( J:131055 )

• at E7.5, there is complete absence of mesodermal cells between the visceral endoderm and the epiblast

abnormal primitive streak morphology ( J:131055 )

• mutant embryos display abnormal thickening of the primitive streak at E7.0, resulting in an abnormal embryo shape

• there is accumulation of cells with mesenchymal morphology in the primitive streak

Allelic Composition	Eomes^tm1.1Rob/Eomes⁺ Wnt3^tm1Brd/Wnt3⁺
Genetic Background	involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)
Wnt3^tm1Brd mutation (0 available); any Wnt3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131055 )

• no phenotypic abnormalities are observed at E9.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal anterior visceral endoderm cell migration ( J:131055 )

• AVE is correctly induced but fails to migrate anteriorly

abnormal developmental patterning ( J:131055 )

• heart patterning abnormalities are observed by E9.5 due to loss of midline structures

abnormal germ layer development ( J:131055 )

• embryos lack visible germ layers

abnormal left-right axis patterning ( J:131055 )

• left-right patterning abnormalities are observed by E9.5 due to loss of midline structures

abnormal rostral-caudal patterning of the somites ( J:131055 )

• floor plate expansion results in increased spacing between somite rows at E9.5

rostral body truncation ( J:131055 )

• by E9.5, mutants lack head structures rostral to the otic placodes

rostral-caudal axis duplication ( J:131055 )

• in the most severely affected embryos, relatively complete duplications of the posterior body axis are observed, including extra somite rows

enlarged floor plate ( J:131055 )

• node abnormalities result in expansion of the floor plate of the neural tube

abnormal notochord morphology ( J:131055 )

• node duplications are accompanied by formation of an accessory notochord

abnormal primitive node morphology ( J:131055 )

• at E8.5, development of the node is severely disturbed in a subset of mutants

• complete node duplications are observed in some mutants

failure of primitive streak formation ( J:131055 )

• the most severely affected double heterozygotes show abnormalities around E7 and fail to form a primitive streak

increased somite number ( J:131055 )

• addition rows of somites are observed in the most severely affected embryos

disorganized embryonic tissue ( J:131055 )

• by late gastrulation stages, embryos are grossly disorganized

embryonic-extraembryonic boundary constriction ( J:131055 )

• the most severely affected embryos develop pronounced constrictions between the embryonic and extraembryonic regions of the conceptus

abnormal amniotic cavity morphology ( J:131055 )

• embryos frequently show tissue accumulation within the amniotic cavity

nervous system

enlarged floor plate ( J:131055 )

• node abnormalities result in expansion of the floor plate of the neural tube

cellular

abnormal anterior visceral endoderm cell migration ( J:131055 )

• AVE is correctly induced but fails to migrate anteriorly

Allelic Composition	Eomes^tm1.1Rob/Eomes⁺ Nodal^tm4Rob/Nodal^tm4Rob
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)
Nodal^tm4Rob mutation (0 available); any Nodal mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:131055 )

• normal Mendelian numbers are recovered during embryogenesis

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