Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
Prl3d1tm1(cre)Gle mutation
(0 available);
any
Prl3d1 mutation
(16 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation
(4 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
Prl2c2tm1(cre)Gle mutation
(0 available);
any
Prl2c2 mutation
(24 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
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mortality/aging
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• embryos are recovered at every embryonic stage examined, and are born live, but most die within the first postnatal day
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embryo
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• double mutants with wild-type (Sox2-cre E2f7fl/- E28fl/-) placentas appear normal at E10.5 and lack the developmental phenotypes in double null embryos
• Note: Sox2-cre is expressed only in the inner cell mass with no extraembronic tissue expression so the placentas are normal
• however, embryos rescued from lethality during development die within a few days of birth
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• significant numbers of apoptotic cells are detected in branchial arches and somites at E10.5
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respiratory system
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• significant ectopic proliferation and apoptosis of pulmonary cells is observed in lungs at P1, but lungs do not appear overtly hypoplastic
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
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cellular
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• MEFs isolated from E13.5 double mutants and infected with a cre recombinase-expressing retrovirus are hypersensitive to DNA damage (camptothecin or cisplatin treatment)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f7tm1Gle mutation
(0 available);
any
E2f7 mutation
(32 available)
E2f8tm1Gle mutation
(0 available);
any
E2f8 mutation
(34 available)
Tg(Cyp19a1-cre)5912Gle mutation
(0 available)
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mortality/aging
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• no live mutant embryos are recovered after E10.5
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growth/size/body
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• displayed by live embryos at E10.5
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embryo
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• displayed by live embryos at E10.5
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• significant numbers of apoptotic cells are detected in branchial arches at E10.5
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• embryos show collapsed labyrinth-like placental architecture
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cardiovascular system
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• observed at E10.5 along with vascular dilation
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