All Phenotypes Wnt4<tm1.1Bhr> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Amhr2^tm3(cre)Bhr/Amhr2⁺ Wnt4^tm1Amc/Wnt4^tm1.1Bhr	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J	MGI:5006679
cn2	Wnt4^tm1.1Bhr/Wnt4^tm1.1Bhr Tg(Prrx1-cre)1Cjt/0	involves: 129S7/SvEvBrd * C57BL/6J	MGI:6458883

Allelic Composition	Amhr2^tm3(cre)Bhr/Amhr2⁺ Wnt4^tm1Amc/Wnt4^tm1.1Bhr
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2^tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (24 available)
Wnt4^tm1.1Bhr mutation (1 available); any Wnt4 mutation (23 available)
Wnt4^tm1Amc mutation (2 available); any Wnt4 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:171430 )

N	• Mullerian duct regression is normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

decreased femoral compact bone area ( J:293133 )

• at 16 weeks of age, females, but not males, show a significant reduction in femoral cortical area at the femoral mid-diaphysis relative to wild-type controls

skeleton

decreased femoral compact bone area ( J:293133 )

• at 16 weeks of age, females, but not males, show a significant reduction in femoral cortical area at the femoral mid-diaphysis relative to wild-type controls

decreased areal bone mineral density ( J:293133 )

• at 16 weeks of age, females, but not males, show a significant reduction in femoral areal bone mineral density (aBMD) relative to wild-type controls

• however, total body bone mineral density is normal in both sexes

decreased bone mineral density of femur ( J:293133 )

• at 16 weeks of age, females, but not males, show a significant reduction in femoral areal bone mineral density (aBMD) relative to wild-type controls

decreased bone trabecula number ( J:293133 )

• at 16 weeks of age, both females and males show a significant reduction in trabecular number at the femoral metaphysis relative to wild-type controls

decreased trabecular bone mass ( J:293133 )

• at 16 weeks of age, females show a significant reduction in trabecular bone mass in the femur relative to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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