About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-Atrnl1)B4Tmg
transgene insertion B4, Teresa M Gunn
MGI:3773113
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Tg(ACTB-Atrnl1)B4Tmg/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3773153
cx2
 		Atrnmg-3J/Atrnmg-3J
Tg(ACTB-Atrnl1)B4Tmg/0 		involves: C3HeB/FeJ * C57BL/6 * DBA/2 MGI:3773148
cx3
 		Pepddal/Pepddal
Tg(ACTB-Atrnl1)B4Tmg/0 		involves: C57BL/6 * CBA/J * DBA/J MGI:5605683


Genotype
MGI:3773153
cx1
Allelic
Composition		 AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Tg(ACTB-Atrnl1)B4Tmg/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
AtrnGt(PST112)Byg mutation (0 available); any Atrn mutation (89 available)
Tg(ACTB-Atrnl1)B4Tmg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:130463 )
• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background
abnormal myelination ( J:130463 )
• hypomyelination observed in homozygotes is partially rescued

integument
integument phenotype ( J:130463 )
N
• unlike homozygotes, mice display a wild-type coat color




Genotype
MGI:3773148
cx2
Allelic
Composition		 Atrnmg-3J/Atrnmg-3J
Tg(ACTB-Atrnl1)B4Tmg/0
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atrnmg-3J mutation (2 available); any Atrn mutation (89 available)
Tg(ACTB-Atrnl1)B4Tmg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
brain vacuoles ( J:130463 )
• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months
• mild to moderate vacuolation occurs at 6 months
• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background

pigmentation
darkened coat color ( J:130463 )
• mice exhibit a partially rescued coat color that is described as dark agouti

integument
darkened coat color ( J:130463 )
• mice exhibit a partially rescued coat color that is described as dark agouti




Genotype
MGI:5605683
cx3
Allelic
Composition		 Pepddal/Pepddal
Tg(ACTB-Atrnl1)B4Tmg/0
Genetic
Background		 involves: C57BL/6 * CBA/J * DBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pepddal mutation (1 available); any Pepd mutation (37 available)
Tg(ACTB-Atrnl1)B4Tmg mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
darkened coat color ( J:143333 )
• transgenic overexpression of attractin does not alter the darkened dorsal coat color of dark-like homozygotes

pigmentation
darkened coat color ( J:143333 )
• transgenic overexpression of attractin does not alter the darkened dorsal coat color of dark-like homozygotes

endocrine/exocrine glands
abnormal testis morphology ( J:143333 )
• transgenic overexpression of attractin does not prevent the formation of testicular vacuoles, which are found by 5 months of age

reproductive system
abnormal testis morphology ( J:143333 )
• transgenic overexpression of attractin does not prevent the formation of testicular vacuoles, which are found by 5 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory