Phenotypes associated with this allele

• Allele Symbol: Tg(ACTB-Atrnl1)B4Tmg
• Allele Name: transgene insertion B4, Teresa M Gunn
• Allele ID: MGI:3773113
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Atrn^Gt(PST112)Byg/Atrn^Gt(PST112)Byg Tg(ACTB-Atrnl1)B4Tmg/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3773153
cx2	Atrn^mg-3J/Atrn^mg-3J Tg(ACTB-Atrnl1)B4Tmg/0	involves: C3HeB/FeJ * C57BL/6 * DBA/2	MGI:3773148
cx3	Pepd^dal/Pepd^dal Tg(ACTB-Atrnl1)B4Tmg/0	involves: C57BL/6 * CBA/J * DBA/J	MGI:5605683

Genotype
MGI:3773153

cx1

• Allelic Composition: Atrn^{Gt(PST112)Byg}/Atrn^{Gt(PST112)Byg}; Tg(ACTB-Atrnl1)B4Tmg/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

brain vacuoles ( J:130463 )

• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months

• mild to moderate vacuolation occurs at 6 months

• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background

abnormal myelination ( J:130463 )

• hypomyelination observed in homozygotes is partially rescued

integument

integument phenotype ( J:130463 )

N • unlike homozygotes, mice display a wild-type coat color

Genotype
MGI:3773148

cx2

• Allelic Composition: Atrn^mg-3J/Atrn^mg-3J; Tg(ACTB-Atrnl1)B4Tmg/0
• Genetic Background: involves: C3HeB/FeJ * C57BL/6 * DBA/2

nervous system

brain vacuoles ( J:130463 )

• brain vacuolation is rescued with only sparse, scattered vacuoles observed at 3 months

• mild to moderate vacuolation occurs at 6 months

• Background Sensitivity: rescue of vacuolation occurs on both a C3H/HeJ and C57BL/6J background

pigmentation

darkened coat color ( J:130463 )

• mice exhibit a partially rescued coat color that is described as dark agouti

integument

darkened coat color ( J:130463 )

• mice exhibit a partially rescued coat color that is described as dark agouti

Genotype
MGI:5605683

cx3

• Allelic Composition: Pepd^dal/Pepd^dal; Tg(ACTB-Atrnl1)B4Tmg/0
• Genetic Background: involves: C57BL/6 * CBA/J * DBA/J

integument

darkened coat color ( J:143333 )

• transgenic overexpression of attractin does not alter the darkened dorsal coat color of dark-like homozygotes

pigmentation

darkened coat color ( J:143333 )

• transgenic overexpression of attractin does not alter the darkened dorsal coat color of dark-like homozygotes

endocrine/exocrine glands

abnormal testis morphology ( J:143333 )

♂ • transgenic overexpression of attractin does not prevent the formation of testicular vacuoles, which are found by 5 months of age

reproductive system

abnormal testis morphology ( J:143333 )

♂ • transgenic overexpression of attractin does not prevent the formation of testicular vacuoles, which are found by 5 months of age