Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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mortality/aging
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• mice die between E13.5 and E14.5 likely due to regurgitation of blood into the heart
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cardiovascular system
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• endocardial cushions form at the level of the semilunar valve but functional flaps do not form
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• at E13.5, mice exhibit incomplete septation of the ventricles
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homeostasis/metabolism
Allelic Composition |
Sox4tm1.1Vlf/Sox4+
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Genetic Background |
involves: 129 * C57BL/6 * FVB/N |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tead2tm1Hssk mutation
(1 available);
any
Tead2 mutation
(31 available)
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cardiovascular system
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• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
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• higher incident than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
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embryo
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• at E11.5, mice exhibit cell death around the notochord in the lumbar, but not thoracic, region compared with wild-type mice
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skeleton
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• more severe and more frequent than in Tead2tm1Hssk homozygotes and Sox4tm1.1Vlf Sox11tm2.2Weg heterozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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mortality/aging
nervous system
cardiovascular system
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• at E9.5, mice lack heart coiling unlike wild-type mice
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craniofacial
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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embryo
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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growth/size/body
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
|
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mortality/aging
skeleton
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• hypomineralized skull with wide sutures
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• hypoplastic
• the last two or three sternebrae are misshapen and irregularly mineralized
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• the xiphoid process is misshapen and irregularly mineralized
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• unfused lumbar vertebral bodies
• L4 and L5 are duplicated
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• hypomineralized skull
• the last two or three sternebrae and the xiphoid process are irregularly mineralized
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cardiovascular system
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• incomplete ventricular septation
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vision/eye
N |
• mice exhibit normal eyes
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craniofacial
N |
• mice exhibit normal palate and lip formation
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• hypomineralized skull with wide sutures
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hematopoietic system
immune system
growth/size/body
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• in 50% of mice in one of 2 crosses
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
|
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mortality/aging
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• mice die between E14.5 and E16.5
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cardiovascular system
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• hypoplastic semilunar valves
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skeleton
vision/eye
respiratory system
craniofacial
homeostasis/metabolism
muscle
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
|
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mortality/aging
nervous system
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• thin at E9.5
• increased cell death and decreased cell proliferation
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• rostrally open neural tube at E9.5
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• undulated neural tube at E9.5
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cardiovascular system
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• unfused heart primordia at E9.5
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cellular
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• at E9.5, mice exhibit increased cell death in the neural tube, branchial arches, and somites unlike in wild-type mice
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• cell proliferation in the neural tube, branchial arches, and somites is reduced compared to in wild-type mice
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craniofacial
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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embryo
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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• increased cell death and decreased cell proliferation
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• thin at E9.5
• increased cell death and decreased cell proliferation
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• rostrally open neural tube at E9.5
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• undulated neural tube at E9.5
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• rudimentary with increased cell death and decreased cell proliferation
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growth/size/body
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• branchial arch mesenchyme is loose and small compared to in wild-type mice
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limbs/digits/tail
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox12tm2.1Weg mutation
(0 available);
any
Sox12 mutation
(8 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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cardiovascular system
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• incomplete ventricular septation
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skeleton
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• fusion and /or deletion
• split sternal bars in all mice
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• vertebral body duplication in all mice
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craniofacial
immune system
hematopoietic system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox12tm2.1Weg mutation
(0 available);
any
Sox12 mutation
(8 available)
Sox4tm1.1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
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embryo
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• thin
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
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• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
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nervous system
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• thin
• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
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• more severe than in Sox4tm1.1Vlf Sox11tm2.2Weg double homozygotes
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