Phenotypes associated with this allele

• Allele Symbol: Etv6^{tm3(NTRK3)Sho}
• Allele Name: targeted mutation 3, Stuart H Orkin
• Allele ID: MGI:3772780
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Etv6^tm3(NTRK3)Sho/Etv6^+	involves: 129S1/Sv	MGI:3772797
cn2	Etv6^tm3(NTRK3)Sho/Etv6^+ Tg(Wap-cre)11738Mam/0	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3772798
cn3	Etv6^tm3(NTRK3)Sho/Etv6^+ Tg(MMTV-cre)FMam/0	involves: 129S1/Sv * FVB/N	MGI:3772799

Genotype
MGI:3772797

ht1

• Allelic Composition: Etv6^{tm3(NTRK3)Sho}/Etv6⁺
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:130323 )

• some female and very rarely males develop mammary gland tumors due to the leakiness of the allele

• however, mice are otherwise indistinguishable from wild-type mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:130323 )

• some female and very rarely males develop mammary gland tumors due to the leakiness of the allele

• however, mice are otherwise indistinguishable from wild-type mice

integument

increased mammary gland tumor incidence ( J:130323 )

• some female and very rarely males develop mammary gland tumors due to the leakiness of the allele

• however, mice are otherwise indistinguishable from wild-type mice

Genotype
MGI:3772798

cn2

• Allelic Composition: Etv6^{tm3(NTRK3)Sho}/Etv6⁺; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

neoplasm

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:130323 )

♀ • nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

integument

mammary gland alveolar hyperplasia ( J:130323 )

♀ • nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:130323

Genotype
MGI:3772799

cn3

• Allelic Composition: Etv6^{tm3(NTRK3)Sho}/Etv6⁺; Tg(MMTV-cre)FMam/0
• Genetic Background: involves: 129S1/Sv * FVB/N

mortality/aging

premature death ( J:130323 )

• mice develop lethal myeloproliferative disease several weeks after birth

neoplasm

increased chronic myelocytic leukemia incidence ( J:130323 )

• mice develop lethal myeloproliferative disease several weeks after birth