Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-SAC/EGFP)35Rang
• Allele Name: transgene insertion 35, Vivek Rangnekar
• Allele ID: MGI:3772442
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(CAG-SAC/EGFP)35Rang/0 Tg(TRAMP)8247Ng/0	involves: C3H * C57BL/6	MGI:3772457
tg2	Tg(CAG-SAC/EGFP)35Rang/0	involves: C3H * C57BL/6	MGI:3772456

Genotype
MGI:3772457

cx1

• Allelic Composition: Tg(CAG-SAC/EGFP)35Rang/0; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:125633 )

♂ • by 3 months, 50% of mice develop high-grade prostatic intraepithelial neoplasm; by 6 months, only 21.4% of animals have progressed to adenocarcinoma

cellular

increased apoptosis ( J:125633 )

♂ • prostatic adenocarcinomas and epithelial neoplasms show significantly more apoptotic cells relative to tumors in Tg(TRAMP)8247Ng single transgenic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:125633

Genotype
MGI:3772456

tg2

• Allelic Composition: Tg(CAG-SAC/EGFP)35Rang/0
• Genetic Background: involves: C3H * C57BL/6

mortality/aging

mortality/aging ( J:125633 )

N • mice display normal lifespan compared to wild-type mice

neoplasm

decreased tumor incidence ( J:125633 )

• transgenic mice do not develop spontaneous liver tumors or splenic lymphomas in contrast to wild-type controls

• no mice develop prostatic neoplasms

decreased liver tumor incidence ( J:125633 )

• mice do not develop spontaneous hepatocarcinomas or lymphomas in contrast to control wild-type B6C3 hybrid mice and mice expressing only a GFP transgene which develop such liver tumors by ~18 months of age

decreased lymphoma incidence ( J:125633 )

• transgenic mice do not develop spontaneous splenic lymphomas, in contrast to wild-type controls

liver/biliary system

liver/biliary system phenotype ( J:125633 )

N • liver architecture is normal in mice resistant to tumor development

decreased liver tumor incidence ( J:125633 )

• mice do not develop spontaneous hepatocarcinomas or lymphomas in contrast to control wild-type B6C3 hybrid mice and mice expressing only a GFP transgene which develop such liver tumors by ~18 months of age

hematopoietic system

hematopoietic system phenotype ( J:125633 )

N • spleen morphology and architecture is normal in mice

reproductive system

reproductive system phenotype ( J:125633 )

N • transgenic mice have normal-sized litters and both sexes display normal level of fertility

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:125633 )

N • prostate glands are normal