All Phenotypes Olr1<tm1Meht> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Olr1^tm1Meht/Olr1^tm1Meht	B6.129X1-Olr1^tm1Meht/Meht	MGI:3772338
cx2	Ldlr^tm1Her/Ldlr^tm1Her Olr1^tm1Meht/Olr1^tm1Meht	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6	MGI:3772340

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130794 )

N	• cholesterol levels are normal when fed a high cholesterol diet

abnormal response of heart to induced stress ( J:130729 )

• unlike wild-type mice, cardiac function is not impaired following ischemia and reperfusion

• mice exhibit reduced infiltration of inflammatory cells into capillaries in regions affected by cardiac ischemia and reperfusion compared to wild-type mice

• unlike in wild-type mice, creatine kinase-MB levels are decreased indication reduced myocyte death

• mice exhibit less oxidative stress following ischemia and reperfusion compared to wild-type mice

decreased myocardial infarct size ( J:130729 )

• mice exhibit smaller and fewer areas of injury following ischemia and reperfusion

• area affected following ischemia and reperfusion is reduced (23.4+/-3.5% compared to 64.1+/-10.6% in wild-type mice)

increased circulating interleukin-10 level ( J:130794 )

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130794 )

• mice exhibit fewer sudanophilic areas than in wild-type mice

abnormal response of heart to induced stress ( J:130729 )

• unlike wild-type mice, cardiac function is not impaired following ischemia and reperfusion

• mice exhibit reduced infiltration of inflammatory cells into capillaries in regions affected by cardiac ischemia and reperfusion compared to wild-type mice

• unlike in wild-type mice, creatine kinase-MB levels are decreased indication reduced myocyte death

• mice exhibit less oxidative stress following ischemia and reperfusion compared to wild-type mice

decreased myocardial infarct size ( J:130729 )

• mice exhibit smaller and fewer areas of injury following ischemia and reperfusion

• area affected following ischemia and reperfusion is reduced (23.4+/-3.5% compared to 64.1+/-10.6% in wild-type mice)

immune system

increased circulating interleukin-10 level ( J:130794 )

muscle

increased muscle relaxation ( J:130794 )

• the basal relaxation response to Ach in the aortic ring is increased compared to in wild-type mice and mice do not respond to oxLDL treatment that blocks relaxation of the aortic rings in wild-type mice

Allelic Composition	Ldlr^tm1Her/Ldlr^tm1Her Olr1^tm1Meht/Olr1^tm1Meht
Genetic Background	involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)
Olr1^tm1Meht mutation (0 available); any Olr1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:130794 )

• when fed a high-cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for HDL of 0.77 compared to 0.83 in wild-type mice

increased circulating LDL cholesterol level ( J:130794 )

• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for LDL of 0.88 compared to 0.84 in wild-type mice

increased circulating VLDL cholesterol level ( J:130794 )

• when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for VLDL of 0.92 compared to 0.88 in wild-type mice

increased circulating interleukin-10 level ( J:130794 )

• IL-10 levels are increased compared to in Ldlr^tm1Her homozygotes

cardiovascular system

decreased susceptibility to atherosclerosis ( J:130794 )

• mice exhibit less intimal thickening and sudanophilic areas than in Ldlr^tm1Her homozygotes

• mice do not exhibit endothelial disruption as in Ldlr^tm1Her homozygotes

immune system

increased circulating interleukin-10 level ( J:130794 )

• IL-10 levels are increased compared to in Ldlr^tm1Her homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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