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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trim24tm1Los
targeted mutation 1, Regine Losson
MGI:3772050
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Raratm3Ipc/Raratm3Ipc
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los 		involves: 129/Sv * C57BL/6 * DBA * SJL MGI:3772096
cn2
 		Raratm3Ipc/Rara+
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los 		involves: 129/Sv * C57BL/6 * DBA * SJL MGI:3772097


Genotype
MGI:3772096
cn1
Allelic
Composition		 Raratm3Ipc/Raratm3Ipc
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm3Ipc mutation (0 available); any Rara mutation (80 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Trim24tm1Los mutation (0 available); any Trim24 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:130210 )
• slight but significant increase in the percentage of Ki67-positive hepatocytes from 14 week old mice compared to age-matched control mice

cellular
increased hepatocyte proliferation ( J:130210 )
• slight but significant increase in the percentage of Ki67-positive hepatocytes from 14 week old mice compared to age-matched control mice




Genotype
MGI:3772097
cn2
Allelic
Composition		 Raratm3Ipc/Rara+
Speer6-ps1Tg(Alb-cre)21Mgn/?
Trim24tm1Los/Trim24tm1Los
Genetic
Background		 involves: 129/Sv * C57BL/6 * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Raratm3Ipc mutation (0 available); any Rara mutation (80 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Trim24tm1Los mutation (0 available); any Trim24 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:130210 )
• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver

cellular
increased hepatocyte proliferation ( J:130210 )
• the number of Ki67-positive hepatocytes is 1.5-fold greater compared to age-matched control mice but 1.5 fold less than hepatocytes from homozygous mice conditionally null for Trim24 in the liver




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory