Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
|
|
|
normal phenotype
|
|
• mice did not exhibit any obvious phenotype
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation
(1 available);
any
Rps6kb1 mutation
(55 available)
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
|
|
|
mortality/aging
|
|
• lethality is comparable to that observed on a mixed background
|
|
|
• lethality is comparable to that observed on a mixed background
|
|
|
• lethality is comparable to that observed on a mixed background
|
growth/size/body
|
|
• growth retardation is comparable to that observed on a mixed background
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
Tg(Ins2-Akt1*)3Mbb mutation
(0 available)
|
|
|
endocrine/exocrine glands
|
|
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age
|
neoplasm
|
|
• mice develop insulinomas with a 26% penetrance between 10 and 20 months of age
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation
(1 available);
any
Rps6kb1 mutation
(55 available)
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
|
|
|
muscle
|
|
• muscle cells are resistant to the growth inhibition triggered by rapamycin or nutrient deprivation
• however, sensitivity to rapamycin and nutrient deprivation could be restored by transfection of a constitutively active AMPK
|
|
|
• muscle cell diameter is reduced by 20% compared to wild-type (6.2+/-0.2 um compared to 8.9+/-0.5 um for wild-type cells in culture)
|
|
|
• ATP levels in muscle cells is reduced 34% and AMP levels are increased 40% compared to in wild-type mice
• mitochondrial enzyme activity of citrate synthase and cytochrome c oxidase in myotubes is increased 50% to 70% compared to wild-type
|
homeostasis/metabolism
cellular
|
|
• mitochondrial mass in myotubes and white adipose tissue is increased compared to in wild-type mice
|
|
|
• ATP-dependent and -independent oxidative capacity is increased in skeletal muscle
|
|
|
• mitochondrial fatty acid beta-oxidation was also augmented in mutant muscle cell cultures, as measured by [3H]-palmitate oxidation
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation
(1 available);
any
Rps6kb1 mutation
(55 available)
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
|
|
|
mortality/aging
|
|
• only 65% of expected embryos survive until weaning
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation
(1 available);
any
Rps6kb1 mutation
(55 available)
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
|
|
|
mortality/aging
|
|
• half of the mice that are born alive die within hours with signs of cyanosis
• however, mice that survive day 1 usually reach adulthood
|
|
|
• one third of mice are born dead without having emerged from their yolk sacs or detached from their placenta
|
|
|
• only 30% of expected embryos survive until weaning
|
cardiovascular system
|
|
• nonviable and cyanotic mice exhibit dilated heart chambers
|
|
|
• nonviable and cyanotic mice exhibit hyperemia of internal organs
|
|
|
• nonviable mice exhibit several sites of hemorrhaging and red blood cells are detected throughout the myocardium
red blood cells are detected throughout the myocardium
|
homeostasis/metabolism
growth/size/body
|
|
• mice exhibit the same growth rate as Rps6kb1tm1Gtho homozygotes
|
reproductive system
|
|
• mice produce small litters that exhibit a high incidence of perinatal lethality
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation
(1 available);
any
Rps6kb1 mutation
(55 available)
Rps6kb2tm1Gtho mutation
(0 available);
any
Rps6kb2 mutation
(21 available)
Tg(Ins2-Akt1*)3Mbb mutation
(0 available)
|
|
|
endocrine/exocrine glands
|
|
• pancreatic beta cells are 4-fold larger than wild-type cells
|
neoplasm
|
N |
• mice do not develop insulinomas
|
Analysis Tools
