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Targeted Allele Detail
Symbol: Rps6kb2tm1Gtho
Name: ribosomal protein S6 kinase, polypeptide 2; targeted mutation 1, George Thomas
MGI ID: MGI:3771299
Synonyms: S6K2-
Gene: Rps6kb2  Location: Chr19:4206791-4213382 bp, - strand  Genetic Position: Chr19, 3.86 cM, cytoband A
Alliance: Rps6kb2tm1Gtho page
Germline Transmission:  Earliest citation of germline transmission: J:89696
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 8 through 11 were replaced with a neo cassette. These exons encode the T loop, APE motif and the catalytic domain of the protein. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:89696)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rps6kb2 Mutation:  21 strains or lines available
Original:  J:89696 Pende M, et al., S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol. 2004 Apr;24(8):3112-24
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.13
The Jackson Laboratory