Rps6kb2^tm1Gtho
Targeted Allele Detail

Summary

• Symbol: Rps6kb2^tm1Gtho
• Name: ribosomal protein S6 kinase, polypeptide 2; targeted mutation 1, George Thomas
• MGI ID: MGI:3771299
• Synonyms: S6K2^-
• Gene: Rps6kb2 Location: Chr19:4206791-4213382 bp, - strand Genetic Position: Chr19, 3.86 cM, cytoband A
• Alliance: Rps6kb2^tm1Gtho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89696
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 8 through 11 were replaced with a neo cassette. These exons encode the T loop, APE motif and the catalytic domain of the protein. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:89696)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6kb2 Mutation: 21 strains or lines available

References

• Original: J:89696 Pende M, et al., S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol. 2004 Apr;24(8):3112-24
• All: 27 reference(s)