Phenotypes associated with this allele

• Allele Symbol: Als2^tm1Deng
• Allele Name: targeted mutation 1, Han-Xiang Deng
• Allele ID: MGI:3770658
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Als2^tm1Deng/Als2^tm1Deng	involves: 129	MGI:3770664
cx2	Als2^tm1Deng/Als2^tm1Deng Tg(SOD1*G93A)1Gur/?	involves: 129/Sv * C57BL/6 * SJL	MGI:3770665

Genotype
MGI:3770664

hm1

• Allelic Composition: Als2^tm1Deng/Als2^tm1Deng
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:129939 )

• mice have a 32% reduction in length of time they able to stay on a rotating platform that is accelerating

nervous system

abnormal corticospinal tract morphology ( J:129939 )

• degeneration is detected in the dorsal regions of the corticospinal tracts of adult mice

neurodegeneration ( J:129939 )

• mild degeneration is detected by silver staining in the dorsal regions of the corticospinal tracts of adult mice

Genotype
MGI:3770665

cx2

• Allelic Composition: Als2^tm1Deng/Als2^tm1Deng; Tg(SOD1*G93A)1Gur/?
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

mortality/aging

premature death ( J:129939 )

• all mice die of a neurodegenerative disorder by 150 days of age

nervous system

neurodegeneration ( J:129939 )

• mice display neurodegeneration similar to mice with just the Tg(SOD1*G93A)1Gur transgene