Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-Lmp2a)ERlon
• Allele Name: transgene insertion E, Richard Longnecker
• Allele ID: MGI:3769768
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Igh-Lmp2a)ERlon/0	involves: C57BL/6 * SJL	MGI:3769777

Genotype
MGI:3769777

tg1

• Allelic Composition: Tg(Igh-Lmp2a)ERlon/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell proliferation ( J:129571 )

• unlike wild-type cells, B cells survive and proliferate when cultured in media containing IL-7 and these cells are IgM-

decreased B cell number ( J:129571 )

• the proportion and number of CD19+ B cells in the spleen is reduced compared to in wild-type mice and those present are negative for IgM unlike in wild-type mice

hematopoietic system

abnormal B cell proliferation ( J:129571 )

• unlike wild-type cells, B cells survive and proliferate when cultured in media containing IL-7 and these cells are IgM-

decreased B cell number ( J:129571 )

• the proportion and number of CD19+ B cells in the spleen is reduced compared to in wild-type mice and those present are negative for IgM unlike in wild-type mice

cellular

abnormal B cell proliferation ( J:129571 )

• unlike wild-type cells, B cells survive and proliferate when cultured in media containing IL-7 and these cells are IgM-